Mechanism of Oxidative C─H Bond Activation by De Novo Designed Artificial Cu Metalloenzymes Using H

Divyansh Prakash, Yao Wu, Sandeep K Misra, Nishanthini Sampath, Binju Wang, Saumen Chakraborty

Abstract read

In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Divyansh PrakashDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.

Yao WuState Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China.

Sandeep K MisraDepartment of Biomolecular Sciences, University of Mississippi, University, MS, 38677, United States.

Nishanthini SampathDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.

Binju WangState Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P. R. China.

Saumen ChakrabortyDepartment of Chemistry and Biochemistry, University of Mississippi, University, MS, 38677, USA.ORCID 0000-0002-9256-2769

Funding

Tracking Glycosylation State with Fluorinated Glycosides ProbesP20GM130460 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI Joshua S Sharp · 2020 to 2026

$17.9M

Foundation for the National Institutes of Health P20GM130460NIGMS NIH HHS P20 GM130460University of Mississippi

6 · The paper itself

Abstract

De novo-designed artificial Cu protein (ArCuP), 3SCC, featuring a trigonal Cu(His)

Indexed as

CopperHydrogen PeroxideMetalloproteinsOxygenBenzaldehydesBenzyl AlcoholCatalysisCatalytic DomainMixed Function OxygenasesOxidation-ReductionbenzaldehydeBenzaldehydesBenzyl AlcoholCopperHydrogen PeroxideMetalloproteinsMixed Function OxygenasesOxygen

Identifiers

PMID40801149

DOI10.1002/chem.202501245

PMCPMC13198777

What Socratic holds

Textmetadata

LicenceTDM

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.