Evidence map›Paper›PMID 40801171›Full record

ArticleJournal of the peripheral nervous system : JPNS2025

Influence of Genomic Ancestry and Other Traditional Risk Factors on the Prevalence of Diabetic Peripheral Neuropathy in Admixed Individuals With Type 1 Diabetes in Brazil: A Pioneer Multicenter Study.

Cejana Hamu Aguiar, Hermelinda Cordeiro Pedrosa, Lucianne Righeti Monteiro Tannus, Livia Leite Ferreira, Dayse Silva, Luís Cristóvão Porto, Carlos Antonio Negrato, Marilia Brito Gomes

Abstract readMulticenter Study
In one paragraph

Article in Journal of the peripheral nervous system : JPNS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cejana Hamu AguiarResearch Center of Foundation for Education and Research in Health Sciences, Endocrinology Unit of the Regional Hospital of Taguatinga, Secretariat of Health of the Federal District, Brasília, Brazil.
Hermelinda Cordeiro PedrosaResearch Center of Foundation for Education and Research in Health Sciences, Endocrinology Unit of the Regional Hospital of Taguatinga, Secretariat of Health of the Federal District, Brasília, Brazil.
Lucianne Righeti Monteiro TannusDepartment of Internal Medicine, Diabetes Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Livia Leite FerreiraDNA Diagnostic Laboratory, Rio de Janeiro State University, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-2636-7890
Dayse SilvaDNA Diagnostic Laboratory, Rio de Janeiro State University, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-3805-2837
Luís Cristóvão PortoHistocompatibility and Cryopreservation Laboratory (HLA), Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil.
Carlos Antonio NegratoUniversity of Sao Paulo, Faculty of Medicine of Bauru, Bauru, Brazil.
Marilia Brito GomesDepartment of Internal Medicine, Diabetes Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-4458-4741

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304367/2021-4Conselho Nacional de Desenvolvimento Científico e Tecnológico 563753/2010-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.602580/2021-00Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 260003/001128/2020Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 26/110.170/2013Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 26/200.521/2023Sociedade Brasileira de Diabetes
6 · The paper itself

Abstract

aimsTo assess the influence of genomic ancestry (GA) and other traditional risk factors on the prevalence of diabetic peripheral neuropathy (DPN) in admixed Brazilian individuals with type 1 diabetes (T1D).

methodsThis cross-sectional, multicenter, pioneer study was conducted in 14 public clinics in 10 Brazilian cities. From 1760 individuals, 1732 were included (98.4%), aged 29.9 ± 11.9 years, diabetes duration 15.4 ± 9.2 years, 968 females (55.9%), 939 (55.7%) self-reported as White. DPN was evaluated by the validated neuropathy disability score (NDS) and neuropathy symptoms score (NSS).

resultsThe prevalence of DPN was 14.8%. In hierarchical multivariate logistic regression, the covariates associated with DPN were age, diabetes duration, HbA1c, type of health care insurance, insulin therapeutic regimen, number of yearly clinical visits, low exercise practice rates, hypertension, dyslipidemia, heart rate, statin use, uric acid levels, lower health-related quality of life, presence of diabetic retinopathy, and amputations. Among the sociodemographic characteristics, African GA, a contemporary emerging factor, showed the highest association.

conclusionsDPN was related to several comorbidities, diabetes-related complications, and lower health-related quality of life. These individuals were young, implying a high lifetime cost of this disease. The association with the emerging factor African GA warrants further studies involving other admixed populations.

Indexed as

Diabetes Mellitus, Type 1Diabetic NeuropathiesAdolescentAdultBrazilCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceRisk FactorsYoung Adultdiabetic peripheral neuropathygenomic ancestryself‐reported color‐racetype 1 diabetes

Identifiers

PMID40801171
PMCPMC12344750

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.