Evidence map›Paper›PMID 40801595›Full record

ArticleCells2025

NR2F6 as a Disease Driver and Candidate Therapeutic Target in Experimental Cerebral Malaria.

Victoria E Stefan, Victoria Klepsch, Nikolaus Thuille, Martina Steinlechner, Sebastian Peer, Kerstin Siegmund, Peter Lackner, Erich Schmutzhard, Karin Albrecht-Schgör, Gottfried Baier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Inhibition ofBiomedicines · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Victoria E StefanResearch Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, University Hospital of the Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
Victoria KlepschInstitute for Cell Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0003-4146-4664
Nikolaus ThuilleInstitute for Cell Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-2253-3946
Martina SteinlechnerInstitute for Cell Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0009-0008-8925-8484
Sebastian PeerInternal Medicine V (Hematology and Oncology), Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-4372-5365
Kerstin SiegmundInstitute for Cell Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-3654-1170
Peter LacknerVienna Healthcare Group, Department of Neurology, Klinik Floridsdorf, 1010 Vienna, Austria.
Erich SchmutzhardDepartment of Neurology, Medical University of Innsbruck, 6020 Innsbruck, Austria.
Karin Albrecht-SchgörInstitute for Cell Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0009-0007-0336-7130
Gottfried BaierInstitute for Cell Genetics, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-2085-8325

Funding

European Research Council Fund ADG 786462European Research Council Fund PoC 101189004FWF Austrian Science Fund P31383FWF Austrian Science Fund P34368FWF Austrian Science Fund PAT1317523FWF Austrian Science Fund T1292FWF Austrian Science Fund TAI80
6 · The paper itself

Abstract

Cerebral malaria (CM) is the severe progression of an infection with

Indexed as

Malaria, CerebralAnimalsBlood-Brain BarrierBrainCD8-Positive T-LymphocytesDisease Models, AnimalMiceMice, Inbred C57BLMice, KnockoutPlasmodium bergheiCD8+ T cell brain infiltrationcompromised blood–brain barrier (BBB) integrityexperimental cerebral malaria (ECM)group Finnovative pharmacological therapy solution for CMmember 6 (NR2F6)nuclear receptor subfamily 2

Identifiers

PMID40801595
PMCPMC12345861

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.