Evidence map›Paper›PMID 40801633›Full record

ArticleCells2025

Pre-Conception Maternal Obesity Confers Autism Spectrum Disorder-like Behaviors in Mice Offspring Through Neuroepigenetic Dysregulation.

Nina P Allan, Amada Torres, Michael J Corley, Brennan Y Yamamoto, Chantell Balaan, Yasuhiro Yamauchi, Rafael Peres, Yujia Qin, Vedbar S Khadka, Youping Deng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nina P AllanYanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.
Amada TorresYanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.ORCID 0000-0001-7010-1294
Michael J CorleyYanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.
Brennan Y YamamotoYanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.ORCID 0009-0002-0921-6046
Chantell BalaanYanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.
Yasuhiro YamauchiYanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.
Rafael PeresYanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.
Yujia QinBioinformatics Core Facility, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.ORCID 0000-0003-0971-0175
Vedbar S KhadkaBioinformatics Core Facility, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.ORCID 0000-0002-8652-2904
Youping DengBioinformatics Core Facility, Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.
Monika A WardYanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.ORCID 0000-0002-2483-5622
Alika K MaunakeaYanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.ORCID 0000-0002-6457-5087

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Benjamin C. Fogelgren · 2017 to 2026
$59.5M
Tracking and Evaluation CoreU54GM138062 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI SHIKUMA, CECILIA M. · 2021 to 2025
$15.5M
Selenium Metabolism in the Heart: Impact of High Fructose and Low SeleniumP20GM139753 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Marla J Berry · 2022 to 2026
$13.3M
Transgenic Mouse, ICSI and IVF CoreP20GM103457 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI WARD, WILLIAM S · 2012 to 2018
$12.9M
Pacific Center for Genome ResearchU54HG013243 · NHGRI · UNIVERSITY OF HAWAII AT MANOA · PI Alexandra Margaret Lynn Binder, Youping Deng · 2023 to 2026
$10.8M
ULTRASOUND-TARGETED MICROBUBBLE DESTRUCTION IN COMBINATION WITH THE PIGGYBACP20RR024206 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI YAMAZAKI, YUKIKO · 2008 to 2011
$8.4M
Do we need Y chromosome for successful reproduction?R01HD072380 · NICHD · UNIVERSITY OF HAWAII AT MANOA · PI WARD, MONIKA A · 2012 to 2022
$3.7M
Socioecological Determinants of Immunoepigenetic Signatures of Diabetes Risk in Indigenous CommunitiesR01MD016593 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI MAUNAKEA, ALIKA KEOLAOKALANI · 2021 to 2025
$3.3M
The roles of mouse Y chromosome Zfy genes in male reproduction.R01HD114645 · NICHD · UNIVERSITY OF HAWAII AT MANOA · PI Monika A Ward · 2024 to 2026
$1.6M
Epigenomic Dysregulation of Neurodevelopmental Genes Underlies Autism Spectrum DisordersR21MH114005 · NIMH · UNIVERSITY OF HAWAII AT MANOA · PI MAUNAKEA, ALIKA KEOLAOKALANI · 2017 to 2018
$424k
NCRR NIH HHS P20 RR024206NHGRI NIH HHS U54 HG013243NICHD NIH HHS R01 HD072380NICHD NIH HHS R01 HD114645NIGMS NIH HHS P20 GM103457NIGMS NIH HHS P20 GM103466NIGMS NIH HHS P20 GM139753NIGMS NIH HHS U54 GM138062NIH NICHD R01HD072380 and HD114645NIH NIGMS P20GM103457 and P20GM139753NIH NIMH R21MH114005NIH NIMHD R01MD016593NIMHD NIH HHS R01 MD016593NIMHD NIH HHS U54 MD007601NIMH NIH HHS R21 MH114005
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with early-life origins. Maternal obesity has been associated with increased ASD risk, yet the mechanisms and timing of susceptibility remain unclear. Using a mouse model combining in vitro fertilization (IVF) and embryo transfer, we separated the effects of pre-conception and gestational obesity. We found that maternal high fat diet (HFD) exposure prior to conception alone was sufficient to induce ASD-like behaviors in male offspring-including altered vocalizations, reduced sociability, and increased repetitive grooming-without anxiety-related changes. These phenotypes were absent in female offspring and those exposed only during gestation. Cortical transcriptome analysis revealed dysregulation and isoform shifts in genes implicated in ASD, including

Indexed as

Autism Spectrum DisorderBehavior, AnimalEpigenesis, GeneticObesityPregnancy in ObesityPrenatal Exposure Delayed EffectsAnimalsDiet, High-FatDisease Models, AnimalDNA MethylationFemaleHomer Scaffolding ProteinsMaleMiceMice, Inbred C57BLPregnancyHomer Scaffolding ProteinsautismDNA methylationmaternal obesityneuroepigenetics

Identifiers

PMID40801633
PMCPMC12345829

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.