Evidence map›Paper›PMID 40801649›Full record

ArticleCells2025

When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer's Neuropathogenesis.

Jagadeesh Narasimhappagari, Ling Liu, Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, W Sue T Griffin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jagadeesh NarasimhappagariDonald W. Reynolds Department of Geriatrics, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Ling LiuDonald W. Reynolds Department of Geriatrics, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Meenakshisundaram BalasubramaniamDonald W. Reynolds Department of Geriatrics, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Srinivas AyyadevaraDonald W. Reynolds Department of Geriatrics, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.ORCID 0000-0002-4572-6361
W Sue T GriffinDonald W. Reynolds Department of Geriatrics, Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.ORCID 0000-0002-0405-7800

Funding

ROLE OF IL-1 IN ADAPTATION TO EXERCISE IN AGING MUSCLEP01AG012411 · UNIVERSITY OF ARKANSAS MED SCIS LTL ROCK · 1995 to 2005
$6.8M
Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy RescueR01AG084472 · UNIV OF ARKANSAS FOR MED SCIS · 2025 to 2025
$461k
NIA NIH HHS P01 AG012411NIA NIH HHS R01 AG084472Program Project grant, NIH 2P01AG012411-21 A1, R01AG084472
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseApolipoprotein E4Interleukin-1betaNeuroinflammatory DiseasesAgedAged, 80 and overAutophagyFemaleHumansMaleNeurofibrillary TanglesSignal TransductionApolipoprotein E4IL1B protein, humanInterleukin-1betaAPOEε4autophagyInterleukin-1βNeuroinflammation

Identifiers

PMID40801649
PMCPMC12345965

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.