ArticleClinical science (London, England : 1979)2025
The death of a myth: Females are not resistant to acute kidney injury.
Article in Clinical science (London, England : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
There is an important gap of knowledge regarding the mechanisms behind the greater prevalence of chronic kidney disease (CKD) in females compared with males. Most of the published reports suggest that females are protected from acute kidney injury (AKI) and from the AKI-to-CKD transition; however, in this issue of Clinical Science, Moronge et al. demonstrate that female rats present with subclinical markers of kidney damage post-ischemic reperfusion injury despite normalized levels of plasma creatinine. These studies underscore the potential for this AKI-induced subclinical injury to underlie the higher sensitivity of females to develop CKD later in life.
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