ArticleSchizophrenia bulletin2026
Understanding Anticipatory Anhedonia in Schizophrenia and Depression: Linking Reward Representation Maintenance from a Transdiagnostic Perspective.
Article in Schizophrenia bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Effort, timing and choice: a refined rodent effort choice task with excellent sensitivity to dopamine modulators.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and hypothesisAnticipatory anhedonia is common in both schizophrenia (SCZ) and major depressive disorder (MDD). Under the transdiagnostic framework of the Research Domain Criteria, this study investigated how reward representation maintenance relates to anticipatory pleasure in patients with SCZ and MDD. STUDY
designWe recruited 61 SCZ patients, 60 MDD patients, and 77 age-matched healthy controls (HCs). All the participants completed the Reward Representation Maintenance Task, which was designed to measure the capacity of reward representation maintenance and anticipatory pleasure. STUDY
resultsMixed-design analyses of covariance (ANCOVAs) revealed the significant group difference in mismatch rate (MR; F(2,194) = 14.24, P < .001, partial η2 = 0.130) while maintaining reward representation, with both SCZ (P < .001) and MDD (P < .001) patients exhibiting higher MR than HC group. When anticipating rewards, MDD patients showed fewer number of button press (NBR) than HC when facing large rewards (P < .001). SCZ patients slightly differed by showing a significant decrease in NBR for large rewards (P < .001) and an increase for small rewards (P = .006) compared to HC. Additionally, higher MR in both SCZ and MDD patients was significantly associated with a reduced level of NBR of large rewards.
conclusionsOur findings suggest that the common dysfunction in reward representation maintenance may contribute to the emergence of anticipatory anhedonia in SCZ and MDD patients, though there remains nuances. These insights advance our comprehension of the cognitive foundations of anticipatory anhedonia and lay the groundwork for a transdiagnostic approach to comprehend anhedonia effectively.
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