ReviewInternational ophthalmology2025
How has global research on neural degeneration in glaucoma evolved from 1977 to 2025? A pioneering bibliometric insight into trends, impact, and future directions.
Review in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of neuroprotective therapies for visual acuity preservation in retinitis pigmentosa.BMJ open ophthalmology · 2026Pooled it
- Can MicroRNAs serve as reliable biomarkers and novel therapeutic targets in age-related macular degeneration? A systematic review and meta-analysis.Journal of translational medicine · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural degeneration plays a central role in the pathogenesis of glaucoma, contributing to vision loss and disease progression. To identify research gaps and emerging trends, a focused bibliometric analysis of this domain was conducted. This study analyzed global research trends on neural degeneration in glaucoma from 1977 to 2025 using the Web of Science Core Collection (WoSCC), with the search completed on 1 June 2025. The systematic search targeted terms related to nerve degeneration, neuroprotection, glaucomatous axonopathy, optic nerve, and retinal ganglion cells. A total of 3680 relevant documents were retrieved and analyzed using R-bibliometrix, Biblioshiny, and VOSviewer software. Analysis included publication trends, key journals, prolific authors, citation patterns, and collaboration networks. Scientific output increased significantly from the 1990s, peaking with over 200 articles annually by 2019, followed by a moderate decline post-2020. Top journals included Investigative Ophthalmology & Visual Science (314 articles) and Experimental Eye Research (161 articles). Bradford's Law identified a set of core sources contributing the majority of publications. Influential authors included Weinreb RN and Quigley HA, each with over 70 publications. The USA and China led in publication volume, while the USA dominated in citations with approximately 50,918. Co-authorship analysis revealed collaborative clusters, emphasizing the interdisciplinary nature of this field. Trending keywords evolved from foundational terms like "retinal ganglion cells" to advanced topics such as "optical coherence tomography angiography" and "intracellular-pressure." This bibliometric review outlines key patterns in glaucoma neurodegeneration research and highlights opportunities for future scientific inquiry.
Indexed as
Identifiers
40801966What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.