Evidence map›Paper›PMID 40802282›Full record

ArticlemBio2025

COVID-19-associated neuroinflammation and astrocyte death in the brain linked to ORF3a-induced activation of Sur1-mediated ion channels.

Volodymyr Gerzanich, Chenyu Zhang, Jiantao Zhang, Bhargava Teja Sallapalli, Shaokai Pei, Mohamed Nasr, Cigdem Tosun, Yanjin Zhang, Qiyi Tang, J Marc Simard and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Volodymyr Gerzanich *Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Chenyu Zhang *Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Jiantao ZhangDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Bhargava Teja SallapalliDepartment of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
Shaokai PeiDepartment of Microbiology, Howard University College of Medicine, Washington, DC, USA.
Mohamed NasrDrug Development and Preclinical Research Branch, Division of AIDS, NIAID, NIH, Bethesda, Maryland, USA.
Cigdem TosunDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Yanjin ZhangDepartment of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.ORCID 0000-0002-5847-3260
Qiyi TangDepartment of Microbiology, Howard University College of Medicine, Washington, DC, USA.ORCID 0000-0002-6487-2356
J Marc SimardDepartment of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5373-1988
Richard Y ZhaoDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3424-2852

Funding

Sur1-Trpm4 regulation of the pro-inflammatory astrocytic secretome in EAER01NS107262 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI Vladimir Gerzanich · 2022 to 2023
$676k
A Novel Cell-based System for the Search of SARS-CoV-2 ORF3a Inhibitors against COVID-19R21AI175931 · UNIVERSITY OF MARYLAND BALTIMORE · 2025 to 2025
$194k
BLRD VA I01 BX004652National Institute of Allergy and Infectious Diseases R21AI175931National Institute of Allergy and Infectious Diseases SC1AI112785NHLBI NIH HHS R01 HL082517NIAID NIH HHS R21 AI175931NIAID NIH HHS SC1 AI112785NIMHD NIH HHS G12 MD007597NIMHD NIH HHS G12MD007597NINDS NIH HHS R01 NS102589NINDS NIH HHS R01NS102589, R01NS105633NINDS NIH HHS R01 NS105633NINDS NIH HHS R01 NS107262NINDS NIH HHS R01NS107262RRD VA I01 RX003060U.S. Department of Veterans Affairs I01BX004652U.S. Department of Veterans Affairs I01RX003060, I01BX004652
6 · The paper itself

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected individuals with pre-existing medical conditions, such as neurocognitive disorders. Premorbid neurocognitive conditions compounded by COVID-19 can escalate into COVID-associated neurological complications, leading to severe illness or even death. As COVID-19 continues to persist and vaccines lose efficacy against emerging variants, individuals with neurocognitive disorders often experience prolonged symptoms that are further exacerbated by repeated breakthrough infections of highly diversified viral variants due to emergence of new viral mutations. Despite the significance of neurocognitive disorders as risk factors for COVID-19-related mortality and long COVID, the underlying causes remain largely unknown. In this study, we report a link between ORF3a expression and COVID-associated neuroinflammation and neurocytotoxicity in postmortem brain tissues from COVID-19 patients. These findings were further verified through neural cell-based

Indexed as

AstrocytesBrainCOVID-19Ion ChannelsNeuroinflammatory DiseasesSulfonylurea ReceptorsViroporin ProteinsAnimalsFemaleHumansMaleMiceSARS-CoV-2ABCC8 protein, humanIon ChannelsORF3a protein, SARS-CoV-2Sulfonylurea ReceptorsViroporin ProteinsCOVID-19glibenclamideglycyrrhizinneuroinflammation and neurotoxicityORF3areactive astrocytesSARS-CoV-2Sur1-regulated ion channels

Identifiers

PMID40802282
PMCPMC12421821

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.