Evidence map›Paper›PMID 40803402›Full record

ArticleEnvironmental research2025

The influence of ambient air pollution during folliculogenesis, endometrial development, and spermatogenesis on fertility: A study among patients using vitrified donor oocyte in vitro fertilization.

Sarah LaPointe, Jaqueline C Lee, Zsolt P Nagy, Daniel B Shapiro, Howard H Chang, Yifeng Wang, Armistead G Russell, Heather S Hipp, Audrey J Gaskins

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah LaPointeDepartment of Epidemiology, Emory University Rollins School of Public Heath, Atlanta, GA, USA.
Jaqueline C LeeDivision of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
Zsolt P NagyReproductive Biology Associates, Sandy Springs, GA, USA.
Daniel B ShapiroReproductive Biology Associates, Sandy Springs, GA, USA.
Howard H ChangDepartment of Biostatistics and Bioinformatics, Emory University Rollins School of Public Heath, Atlanta, GA, USA.
Yifeng WangSchool of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Armistead G RussellSchool of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Heather S HippDivision of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
Audrey J GaskinsDepartment of Epidemiology, Emory University Rollins School of Public Heath, Atlanta, GA, USA. Electronic address: audrey.jane.gaskins@emory.edu.

Funding

NCATS NIH HHS UL1 TR000424NIEHS NIH HHS R01 ES032446
6 · The paper itself

Abstract

backgroundAir pollution is associated with reduced fertility; however, the independent effects of air pollution exposure during folliculogenesis, endometrial development, and spermatogenesis on human reproduction remains unclear.

objectiveWe investigated the associations between air pollution during critical windows and clinical outcomes of in vitro fertilization (IVF) using patients undergoing vitrified donor oocyte IVF.

methodsWe included 551 non-identified oocyte donors and 1353 recipients who underwent 2533 embryo transfers at Reproductive Biology Associates in Atlanta, Georgia (2008-2019). Daily ambient exposure to air pollutants was estimated using spatiotemporal models linked to residential addresses and averaged over folliculogenesis (90 days before stimulation) and during stimulation in donors, three months and three weeks prior to transfer in recipients, and spermatogenesis (72 days prior to oocyte thaw) in male partners. Multivariable generalized estimating equations were used to estimate adjusted odds ratios (aOR) and 95 % confidence intervals (CI) per interquartile range increase in pollutants in relation to clinical IVF outcomes.

resultsHigher carbon monoxide (CO) exposure during folliculogenesis (aOR = 0.86 95 % CI 0.77, 0.96) and ovarian stimulation (aOR = 0.88 95 % CI 0.79, 0.98) in donors was associated with lower odds of positive pregnancy test. Higher elemental carbon (EC) exposure during folliculogenesis was associated with lower odds of live birth (aOR = 0.87 95 % CI 0.79, 0.96) and higher odds of pregnancy loss (aOR = 1.16 95 % CI 1.02, 1.32). During ovarian stimulation, higher coarse particulate matter (PM

conclusionsPreconception air pollution exposure during both folliculogenesis and spermatogenesis may adversely impact IVF outcomes.

Indexed as

Air PollutantsAir PollutionEndometriumEnvironmental ExposureFertilityFertilization in VitroSpermatogenesisAdultFemaleGeorgiaHumansMaleOocytesOvarian FolliclePregnancyAir PollutantsAir pollutionFertilityFolliculogenesisIn vitro fertilizationReproductionSpermatogenesis

Identifiers

PMID40803402
PMCPMC12366642

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.