Evidence map›Paper›PMID 40804002›Full record

ArticleOncotarget2025

Clinical and analytical validation of MI Cancer Seek®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay.

Valeriy Domenyuk, Kasey Benson, Peggy Carter, Daniel Magee, Jian Zhang, Nitin Bhardwaj, Hongseok Tae, James Wacker, Foram Rathi, Siobhan Miick and 23 more

Abstract readValidation Study
In one paragraph

Article in Oncotarget, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Valeriy Domenyuk *Caris Life Sciences, Irving, TX 75039, USA.
Kasey Benson *Caris Life Sciences, Irving, TX 75039, USA.
Peggy CarterCaris Life Sciences, Irving, TX 75039, USA.
Daniel MageeCaris Life Sciences, Irving, TX 75039, USA.
Jian ZhangCaris Life Sciences, Irving, TX 75039, USA.
Nitin BhardwajCaris Life Sciences, Irving, TX 75039, USA.
Hongseok TaeCaris Life Sciences, Irving, TX 75039, USA.
James WackerCaris Life Sciences, Irving, TX 75039, USA.
Foram RathiCaris Life Sciences, Irving, TX 75039, USA.
Siobhan MiickCaris Life Sciences, Irving, TX 75039, USA.
Aastha KohliCaris Life Sciences, Irving, TX 75039, USA.
Joshua CarrollCaris Life Sciences, Irving, TX 75039, USA.
Lori CuyuganCaris Life Sciences, Irving, TX 75039, USA.
Evelyn PerezCaris Life Sciences, Irving, TX 75039, USA.
Wayeesha ZhangCaris Life Sciences, Irving, TX 75039, USA.
John CollinsCaris Life Sciences, Irving, TX 75039, USA.
Patrick KennedyCaris Life Sciences, Irving, TX 75039, USA.
Jeremy EllisCaris Life Sciences, Irving, TX 75039, USA.
Adam StarkCaris Life Sciences, Irving, TX 75039, USA.
Andrey LoskutovCaris Life Sciences, Irving, TX 75039, USA.
Brittany CuttoneCaris Life Sciences, Irving, TX 75039, USA.
Blake TaylorCaris Life Sciences, Irving, TX 75039, USA.
Rebecca FeldmanCaris Life Sciences, Irving, TX 75039, USA.
Jeff SwensonCaris Life Sciences, Irving, TX 75039, USA.
David BryantCaris Life Sciences, Irving, TX 75039, USA.
Robert Hahn-LowryCaris Life Sciences, Irving, TX 75039, USA.
Raunaq KaushalCaris Life Sciences, Irving, TX 75039, USA.
Jennifer R RibeiroCaris Life Sciences, Irving, TX 75039, USA.
Jim AbrahamCaris Life Sciences, Irving, TX 75039, USA.
Milan RadovichCaris Life Sciences, Irving, TX 75039, USA.
George W SledgeCaris Life Sciences, Irving, TX 75039, USA.
Matthew OberleyCaris Life Sciences, Irving, TX 75039, USA.
David SpetzlerCaris Life Sciences, Irving, TX 75039, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The precision oncology industry has evolved rapidly within the past two decades, although treatment selection remains a complex undertaking. Access to timely, accurate, and comprehensive molecular profiling data is imperative to improving patient outcomes within the expanding sphere of Food and Drug Administration (FDA)-approved targeted therapies. Caris Life Sciences has developed MI Cancer Seek

Indexed as

Biomarkers, TumorExome SequencingGene Expression ProfilingNeoplasmsTranscriptomeAdultChildFemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedPrecision MedicineReproducibility of ResultsBiomarkers, Tumorcompanion diagnosticmolecular profilingnext-generation sequencingprecision oncologysolid tumors

Identifiers

PMID40804002
PMCPMC12581394

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.