SynthesisMolecular psychiatry2025
Biological correlates of temperament: systematic reviews, empirical studies, and a conceptual framework linking neurotransmitter signaling, intrinsic brain activity, and the hyperthymic-depressive spectrum.
Synthesis in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Polarisation of brain dynamics in mania and depression.Dialogues in clinical neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temperament can be conceptualized as the baseline configuration of experience and behavior, contributing to individual differences in activity levels, emotional intensity, and thought patterns. This work aimed to investigate the biological correlates of temperament. First, we performed systematic reviews on the relationship of temperament with the brain's function/structure (characterized via neuroimaging), as well as neurotransmitter signaling (measured in cerebrospinal fluid and blood). Then, we investigated the relationship of temperament with intrinsic brain activity (using resting-state functional MRI) in 122 subjects, as well as dopamine and serotonin levels (measured in platelets) in 25 subjects. The systematic reviews showed heterogeneous data. Our empirical studies showed that: the hyperthymic temperament is associated with decreased intrinsic brain activity in the medial prefrontal cortex/default-mode network, along with increased dopamine levels in platelets; conversely, the depressive temperament is associated with increased intrinsic brain activity in the medial prefrontal cortex/default-mode network, along with decreased dopamine levels in platelets. These data suggest that the hyperthymic temperament may be associated with a baseline configuration of brain activity tilted toward the sensorimotor areas at the expense of the associative areas (related to high dopamine signaling), favoring immediate interaction with the environment and a propensity for action and impulsive behavior; conversely, the depressive temperament may be associated with a baseline configuration of brain activity tilted toward the associative areas at the expense of the sensorimotor areas (related to low dopamine signaling), favoring detachment from the environment and a propensity for thinking/imagery and rumination. Accordingly, these temperaments may represent the physiological counterparts of the manic and depressive states of bipolar disorder.
Indexed as
Identifiers
40804126What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.