ArticleScientific reports2025
Prevalence and determinants of antidepressant non-adherence among patients with major depressive disorder in Ethiopia: a multi-center cross sectional study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Psychotropic medication non-adherence and its determinants among adult psychiatric patients in Ethiopia.Social psychiatry and psychiatric epidemiology · 2026Article
- Patterns of antidepressant treatment changes among adults with major depressive disorder in Northwest Ethiopia: a hospital-based cross-sectional study.Therapeutic advances in psychopharmacology · 2026Article
- The Decision-Making Process of Antidepressant Use Among Patients with Depression: A Grounded Theory Study.Patient preference and adherence · 2026Article
- Patients Reported Adverse Effects of Antidepressants Among Depressive Disorder and Associated Risk Factors: A Multicenter Cross-Sectional Study.Depression and anxiety · 2026Article
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10 authors.
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Abstract
Non-adherence to antidepressant medication is a well-established factor contributing to treatment failure among patients with major depressive disorder. Addressing this issue is crucial not only for enhancing individual patient outcomes but also for alleviating the broader public health burden. The study aimed to assess antidepressant medication non-adherence and its determinants among patients with major depressive disorder at public hospital psychiatric clinics in Ethiopia. Between June 12, 2024, and November 13, 2024, a multicenter cross-sectional study was conducted at public hospital psychiatric clinics in Ethiopia. Antidepressant non-adherence was assessed using a self-reported tablet count tool with pharmacy refill records available in patients' charts at the time of the interview. The severity of adverse drug reactions (ADRs) was evaluated using the Antidepressant Side-Effect Checklist (ASEC), while the Naranjo ADR Probability Scale was employed to determine the likelihood of ADRs. Data analysis was performed using SPSS version 26.0. Frequencies and percentages, were used to describe the characteristics of study participants. For factors associated with antidepressant non-adherence, multivariate logistic regression was conducted. The association between explanatory variable and non-adherence was assessed using odds ratios (ORs) with 95% CIs. The prevalence of antidepressant medication non-adherence was 139 (32.9%). Female gender [AOR = 3.29, 95% CI (2.04, 5.31)], illiteracy [AOR = 2.17, 95% CI (1.35, 3.50)], unemployment [AOR = 3.40, 95% CI (2.15, 5.38)], treatment duration greater than 25 months [AOR = 1.89, 95% CI (1.05, 3.41)], and severe ADRs [AOR = 3.94, 95% CI (1.68, 9.23)] were significantly associated with Antidepressant medication non-adherence. Being female, illiterate, unemployed, having a treatment duration of more than 25 months, and experiencing severe adverse drug reactions were significantly associated with non-adherence. These findings highlight the need for targeted interventions to improve adherence among these high-risk groups.
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