ArticleScientific reports2025
Association between the psychological frailty index and stroke: a cohort study from CHARLS.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A novel nutritional index and risk of edentulism: evidence from cross-sectional, prospective, and trajectory analyses.Lipids in health and disease · 2026Article
- Effects of access to primary healthcare services on health vulnerability among older adults in China: focusing on demographic differences.Frontiers in public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is a leading cause of death and disability worldwide, especially in the aging population. Psychological vulnerability serves as a multidimensional mental health vulnerability state, but there is a lack of large sample studies on its association with stroke. The aim of this study was to investigate the relationship between psychological vulnerability, as quantified by the Psychological Frailty Index, and stroke. This study was based on baseline data from the China Health and Retirement Longitudinal Study (CHARLS), which included 15,284 participants ≥ 45 years of age. PFI was used as a composite measure of psychological vulnerability by quartiles. Stroke was analyzed using Cox logistic regression models to analyze the relationship between PFI and stroke risk, and the dose-response relationship was tested using restricted cubic spline (RCS). Subgroup analyses and interaction tests were performed to assess differences in different populations. In the fully adjusted Cox model, each one-IQR increase in PFI was associated with an 87% higher risk of incident stroke (HR = 1.87, 95% CI 1.54-2.27; P < 0.001). Compared with participants in the lowest PFI quartile (Q1), those in the highest quartile (Q4) exhibited a more than three-fold increased stroke risk (HR = 3.12, 95% CI 1.99-4.91; P < 0.001). Restricted cubic spline analysis demonstrated a linear dose-response relationship between PFI and stroke risk (P for nonlinearity > 0.05). In subgroup analyses, the association between PFI and stroke was significantly modified by age and marital status (P for interaction < 0.05). In this study, we found that psychological vulnerability was significantly positively and linearly associated with stroke risk. Assessment of psychological vulnerability may be an important component of a comprehensive stroke prevention and control strategy, with particular attention to the elderly and those with social support deficits. Future longitudinal studies should be conducted to clarify the causal relationship.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.