SynthesisPhytotherapy research : PTR2025
Modulation of miRNAs by Phytochemicals in Cerebral Ischemia: A Systematic Review of In Vitro and In Vivo Studies.
Synthesis in Phytotherapy research : PTR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Modulation of miRNAs by Phytochemicals in Cerebral Ischemia: A Systematic Review of In Vitro and In Vivo Studies.Phytotherapy research : PTR · 2025Pooled it
- Wild blueberry-derived polyphenol metabolites attenuate telomere shortening in an in vitro model of metabolic syndrome.European journal of nutrition · 2026Article
- Article
- Urinary Exosomal microRNAs as a Novel Approach to Study People with Multiple Sclerosis and Severe Gait Disability: A Preliminary Observation.Non-coding RNA · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Phytochemicals gained substantial interest for their protective action in cerebral ischemia. Additionally, there is a growing body of evidence suggesting that miRs play a role in stroke therapy. However, no systematic review to date has summarized the impact of phytochemicals on miRs modulation and their role in protecting the brain against ischemia. This systematic review aims to assess the current literature on the protective action of phytochemicals in cellular and animal models of stroke, with special focus on the miRs modulation. A literature search was conducted across three databases (PubMed, Scopus, Embase), adhering to PRISMA guidelines. Studies published in English between 2014 and 2024 were included based on relevant keywords. A total of 224 articles were excluded based on their title and/or abstract as they were deemed irrelevant. Furthermore, 4 articles were excluded due to the lack of an English or full-text version. Finally, 14 articles were included in this review. Phytochemicals reverted ischemia-induced changes in miRs expression; that is, they upregulated miR-556-3p, miR-223-3p, miR-1287-5p, miR-214, miR-96, miR-450b-5p, miR-149-5p, miR-375, and downregulated miR-145-5p, miR-124, miR-128-3p, miR-122, miR-181b, miR-155, miR-134, and miR-128-3p. These, in turn, led to an inhibition of apoptosis, inflammation, oxidative stress, ferroptosis, pyroptosis, and activation of Wnt and AMPK signaling. Our analysis indicates that targeting miRs with phytochemicals may inhibit the ischemic injury; thus, it represents a promising tool for the development of new therapeutic strategies for stroke. Given that all of the reviewed studies utilized cellular or animal models, further human clinical trials are necessary to confirm these findings.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.