SynthesisBMC geriatrics2025
Metabolomic insights into late-life depression: a systematic review.
Synthesis in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Multi-Layered Antidepressant Mechanisms of Gami-Soyosan in a Corticosterone-Induced Mouse Model.Journal of microbiology and biotechnology · 2026Article
- Lipid metabolism dysregulation in late-life depression: peripheral metabolic disturbance, central lipid alterations, and dietary modulation.Frontiers in nutrition · 2026Review
- Quality, reliability, and transparency of late-life depression videos on Chinese social media: a cross-sectional study of Douyin, Rednotes, and BiliBili.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late-life depression (LLD) is a prevalent mental health issue that significantly impacts the quality of life in the elderly population. In recent years, metabolomics has emerged as a novel research tool, offering fresh insights into the molecular mechanisms underlying LLD. This systematic review synthesizes metabolomic studies from January 2004 to March 2024, aiming to identify differential metabolites, explore diagnostic and predictive potential, and investigate aberrant metabolic pathways in LLD. A total of 12 relevant studies were included, revealing differential metabolites such as amino acids and fatty acids, as well as associated metabolic pathways. The study's findings provide insights into the prediction and diagnosis of LLD, highlighting the multifaceted metabolic disturbances associated with the condition. By synthesizing existing literature, we highlight the importance of metabolomic research in identifying biomarkers for LLD and potential therapeutic targets, addressing current gaps in understanding the pathophysiology of this condition.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.