ArticleLipids in health and disease2025
Environmental cadmium exposure aggravates renal fibrosis and reduced renal lipid accumulation in diabetic mice.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Environmental Pollution and Its Impact on Kidney Diseases: A Comprehensive Review of Current Evidence.Life (Basel, Switzerland) · 2026Review
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5 authors.
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Abstract
backgroundCadmium (Cd) is a heavy metal with nephrotoxicity. While the harmful effects of Cd exposure on the kidney have been extensively studied, the nephrotoxicity of Cd exposure on diabetic individual remain largely unexplored. Given the widespread Cd pollution and the high prevalence of diabetes, it is imperative to explore the nephrotoxicity and underlying mechanism of Cd exposure on diabetic individual.
methodsIn current study, established diabetic mouse and high glucose cultured HK-2 cells were exposed to CdCl
resultsPresent study showed no significant nephrotoxicity in Cd-exposed healthy mice and Cd-exposed HK-2 cells. However, same dosing Cd activated TGF/SMAD signaling pathway and increased collagen deposition in kidney of diabetic mice and high glucose cultured HK-2 cells. Intriguingly, Cd reduced renal lipids deposition and inhibited fatty acid synthesis both in diabetic mice and high glucose cultured HK-2 cells.
conclusionsOverall, our findings demonstrate that low dosing Cd significantly aggravated renal fibrosis in diabetic mice and high glucose cultured HK-2 cells. It is recommended that diabetic individuals should avoid working in Cd pollution environment and consuming cadmium-contaminated food. Furthermore, we found that Cd reduced lipid deposition in kidney of diabetic mice and high glucose cultured HK-2 cells. The results provide novel insights into renal lipid metabolism in Cd-exposed diabetic individuals.
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