ArticleEndocrinology, diabetes & metabolism2025
Association Between Serum Vitamin D and Albuminuria in Type 2 Diabetes Independent of Inflammatory Markers and Renal Function.
Article in Endocrinology, diabetes & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association Between Serum Vitamin D and Albuminuria in Type 2 Diabetes Independent of Inflammatory Markers and Renal Function.Endocrinology, diabetes & metabolism · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo explore the relationship between serum high-sensitivity C-reactive protein (hs-CRP), tissue necrosis factor-α (TNF-α) and 25-Hydroxyvitamin D (25(OH) vitamin D) with albuminuria in patients with type 2 diabetes mellitus (T2D).
methodsThis was a cross-sectional study of 86 T2D patients divided into categories of with and without albuminuria based on the urine albumin-to-creatinine ratio (UACR). A 25(OH) vitamin D concentration ≤ 15 ng/mL was defined as vitamin D deficiency, within 15-30 ng/mL as vitamin D insufficiency, and > 30 ng/mL as serum 25(OH) vitamin D sufficiency. A hs-CRP level ≤ 2.5 mg/L was considered low, whereas a hs-CRP level > 2.5 mg/L was considered high. TNF-α was classified as low or high with an 8.2 pg/mL cutoff level based on receiver operating characteristic (ROC) curve analysis. P values < 0.05 were considered to be significantly associated with albuminuria.
resultsVitamin D deficiency was significantly more commonly observed among T2D patients with albuminuria than those without albuminuria (adjusted OR = 7.34, 95% CI = 2.3-23.6, p = 0.001). Higher serum TNF-α levels (TNF-α > 8.2 pg/mL) were more frequently associated with the presence of albuminuria in T2D patients (adjusted OR = 6.77, 95% CI = 1.61-28.4; p = 0.009). Similarly, elevated serum hs-CRP levels (hs-CRP > 2.5 mg/L) were more commonly found among patients with T2D and albuminuria than in those without (adjusted OR = 4.7, 95% CI = 1.4-15.8; p = 0.012).
conclusionsVitamin D deficiency is a significant correlate of albuminuria in T2D patients, independent of glomerular filtration rate (GFR) and basic inflammatory markers including hs-CRP and TNF-α. Moreover, serum hs-CRP > 2.5 mg/L and TNF-α > 8.2 pg/mL were each individually associated with a significantly increased likelihood of albuminuria in T2D patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.