SynthesisInternational journal of circumpolar health2025
Effect of habitual cold exposure on brown adipose tissue activity in Arctic adults: a systematic review.
Synthesis in International journal of circumpolar health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Brown Adipose Tissue and Metabolic Markers Differ Between Greenlanders and Danes With Cold Activation.The Journal of clinical endocrinology and metabolism · 2026Article
- What role will physiological resilience play in brown-white fat dynamic in obesity management?Frontiers in pharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brown adipose tissue (BAT) is crucial for non-shivering thermogenesis, a key adaptation for humans in Arctic environments. The discovery of BAT presence in human adults has ignited curiosity due to its potential role in combating obesity, type II diabetes and cardiovascular diseases. Following PRISMA guidelines and preregistration (PROSPERO CRD42023444511) this systematic review aims to describe the evidence of BAT activity among adults living in the Arctic with habitual cold exposure. Systematic searches were conducted in PubMed, Embase, and Scopus as of November 2024. In addition, trial registration searches, manual screening of reference lists, and requests to experts were performed. No restrictions were made regarding study selection. Each study was assessed using the NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Of 429 studies screened, 21 full texts were included for eligibility assessment, and eight studies qualified for inclusion. Due to the heterogeneity of the included studies, a meta-analysis was not pursued. Results indicate high BAT activity in Arctic populations, as supported by increased supraclavicular skin temperatures after cold exposure, thyroid hormone dynamics, and genetic markers linked to BAT. Findings highlight BAT's role in cold adaptation among adults residing in Arctic regions, though methodological limitations remain, necessitating further research.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.