Evidence map›Paper›PMID 40804979›Full record

ArticleAnimals : an open access journal from MDPI2025

Impact of Heat Stress on Gene Expression in the Hypothalamic-Pituitary-Ovarian Axis of Hu Sheep.

Jianwei Zou, Lili Wei, Yishan Liang, Juhong Zou, Pengfei Cheng, Zhihua Mo, Wenyue Sun, Yirong Wei, Jun Lu, Wenman Li and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jianwei ZouCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.ORCID 0000-0002-4840-7550
Lili WeiCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Yishan LiangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Juhong ZouCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.ORCID 0000-0001-7327-5863
Pengfei ChengCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Zhihua MoCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Wenyue SunCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Yirong WeiCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Jun LuCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Wenman LiCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Yulong ShenCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Xiaoyan DengCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Yanna HuangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.ORCID 0000-0001-9376-3311
Qinyang JiangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.ORCID 0000-0002-0835-9347

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat stress (HS) is a major environmental factor negatively impacting the reproductive performance of livestock. This study investigates the molecular mechanisms of heat stress on the hypothalamic-pituitary-ovarian (HPO) axis in Hu sheep. A heat-stressed animal model was established, and high-throughput RNA sequencing (RNA-seq) was employed to analyze gene expression in the hypothalamus, pituitary, and ovarian tissues of both control and heat-stressed groups. The results revealed significant changes in estrus behavior, hormone secretion, and reproductive health in heat-stressed sheep, with a shortened estrus duration, prolonged estrous cycles, and decreased levels of FSH, LH, E

Indexed as

gene expressionheat stressHu sheephypothalamic–pituitary–ovarian (HPO) axisreproductive dysfunction

Identifiers

PMID40804979
PMCPMC12345516

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.