Evidence map›Paper›PMID 40805232›Full record

ReviewCancers2025

The Exposome Perspective: Environmental and Infectious Agents as Drivers of Cancer Disparities in Low- and Middle-Income Countries.

Zodwa Dlamini, Mohammed Alaouna, Tebogo Marutha, Zilungile Mkhize-Kwitshana, Langanani Mbodi, Nkhensani Chauke-Malinga, Thifhelimbil E Luvhengo, Rahaba Marima, Rodney Hull, Amanda Skepu and 12 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Zodwa DlaminiSAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0002, South Africa.ORCID 0000-0002-8012-3646
Mohammed AlaounaSAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0002, South Africa.
Tebogo MaruthaSAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0002, South Africa.ORCID 0000-0002-3622-321X
Zilungile Mkhize-KwitshanaDepartment of Life and Consumer Sciences, College of Agriculture and Science & Environmental Sciences, Science Campus, University of South Africa, Florida 1709, South Africa.ORCID 0000-0002-0373-9973
Langanani MbodiDepartment of Obstetrics and Gynecology, Gynecologic Oncology Unit, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.
Nkhensani Chauke-MalingaDepartment of Plastic, Reconstructive and Aesthetic Surgery, Steve Biko Academic Hospital University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0003-0914-5946
Thifhelimbil E LuvhengoDepartment of Surgery, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Parktown, Johannesburg 2193, South Africa.
Rahaba MarimaSAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0002, South Africa.ORCID 0000-0001-5050-7350
Rodney HullSAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0002, South Africa.
Amanda SkepuNext Generation Health, Division 1, Council for Scientific and Industrial Research, Meiring Naude Road, Brummeria, Pretoria 0001, South Africa.ORCID 0000-0001-8121-5617
Monde NtwasaWolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1QH, UK.ORCID 0000-0002-6400-8867
Raquel DuarteDepartment of Internal Medicine, Division of Translational Research, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa.
Botle Precious DamaneDepartment of Surgery, Faculty of Health Sciences, Steve Biko Academic Hospital, University of Pretoria, Hatfield 0028, South Africa.ORCID 0000-0003-3060-5572
Benny MosoaneDepartment of Anatomical Pathology, National Health Laboratory Services, Tshwane Academic Division, University of Pretoria, Pretoria 0002, South Africa.ORCID 0000-0002-5588-3221
Sikhumbuzo MbathaSAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0002, South Africa.
Boitumelo PhakathiDepartment of Surgery, Nelson R Mandela School of Medicine, University of Kwa-Zulu Natal, 719 Umbilo Road, Durban 4001, South Africa.ORCID 0000-0002-8991-6060
Moshawa KhabaDepartment of Anatomical Pathology, Dr George Mukhari Academic Laboratory, National Health Laboratory Services, Sefako Makgatho Health Sciences University, Ga-Rankuwa 0208, South Africa.
Ramakwana Christinah ChokweDepartment of Chemistry, College of Science, Engineering, and Technology, University of South Africa, Florida Park, Johannesburg 1709, South Africa.ORCID 0000-0002-1006-912X
Jenny EdgeCharlotte Maxeke Hospital, University of Witwatersrand, Johannesburg 2193, South Africa.
Zukile MbitaDepartment of Biochemistry, Microbiology and Biochemistry, University of Limpopo, Sovenga 0727, South Africa.ORCID 0000-0003-3179-8169
Richard KhanyileSAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0002, South Africa.
Thulo MolefiSAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0002, South Africa.ORCID 0000-0003-1236-842X

Funding

African Medical Research Council Clinician Researcher Programme (SAMRC-CRP) 57029South African Medical Research Council (SAMRC) 138139
6 · The paper itself

Abstract

Cancer disparities in low- and middle-income countries (LMICs) arise from multifaceted interactions between environmental exposures, infectious agents, and systemic inequities, such as limited access to care. The exposome, a framework encompassing the totality of non-genetic exposures throughout life, offers a powerful lens for understanding these disparities. In LMICs, populations are disproportionately affected by air and water pollution, occupational hazards, and oncogenic infections, including human papillomavirus (HPV), hepatitis B virus (HBV),

Indexed as

cancer inequitiesenvironmental exposuresepigeneticsexposomeglobal health disparitiesHIV-related cancerslow- and middle-income countries (LMICs)oncogenic infections (HPV, HBV, and H. pylori)

Identifiers

PMID40805232
PMCPMC12345750

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.