Evidence map›Paper›PMID 40805990›Full record

ArticleNutrients2025

The Gut Mycobiome and Nutritional Status in Paediatric Phenylketonuria: A Cross-Sectional Pilot Study.

Malgorzata Ostrowska, Elwira Komoń-Janczara, Bozena Mikoluc, Katarzyna Iłowiecka, Justyna Jarczak, Justyna Zagórska, Paulina Zambrzycka, Silvia Turroni, Hubert Szczerba

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In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Malgorzata OstrowskaDepartment of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland.ORCID 0000-0002-1218-3225
Elwira Komoń-JanczaraDepartment of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland.ORCID 0000-0003-4579-4994
Bozena MikolucDepartment of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, 15-274 Bialystok, Poland.ORCID 0000-0002-8284-6426
Katarzyna IłowieckaNutrition Clinic, Department of Clinical Dietetics, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0001-7776-2060
Justyna JarczakLaboratory of Regenerative Medicine, Preclinical Research and Technology Center, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0002-4357-7681
Justyna ZagórskaDepartment of Food and Nutrition, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-7869-2882
Paulina ZambrzyckaMetabolic Clinic, Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Ludwig Zamenhoff University Children's Clinical Hospital, Medical University of Bialystok, 15-274 Bialystok, Poland.
Silvia TurroniUnit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0003-2345-9482
Hubert SzczerbaDepartment of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland.ORCID 0000-0001-7429-1777

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhenylketonuria (PKU) is a metabolic disorder managed through a strict, lifelong low-phenylalanine diet, which may influence gut microbiome dynamics. While gut bacterial alterations in PKU are increasingly investigated, the fungal community (mycobiome) remains largely unexplored. This study compared gut mycobiome composition and dietary profiles of paediatric PKU patients and healthy controls, stratified by age (<10 and 10-18 years).

methodsStool samples from 20 children (10 PKU, 10 controls) were analysed using ITS1/ITS2 amplicon sequencing. Nutritional status was assessed using Body Mass Index percentiles (Polish standards), and nutrient intake was evaluated from three-day dietary records compared to national reference values. Correlations between fungal taxa and dietary factors were explored.

resultsAlthough alpha diversity did not differ significantly, beta diversity and LEfSe analyses revealed distinct fungal profiles between PKU patients and controls, indicating a trend toward group separation (PERMANOVA: F = 1.54646,

conclusionsDietary treatment in PKU is associated with age-dependent shifts in the gut mycobiome, notably increasing the abundance of taxa such as Eurotiales,

Indexed as

FungiGastrointestinal MicrobiomeMycobiomeNutritional StatusPhenylketonuriasAdolescentChildChild, PreschoolCross-Sectional StudiesDietFecesFemaleHumansMalePilot Projectsfungal dysbiosisgut mycobiomeinternal transcribed spacer (ITS) sequencingpaediatric nutritionphenylketonuria dietphenylketonuria (PKU)

Identifiers

PMID40805990
PMCPMC12348489

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.