Evidence map›Paper›PMID 40806092›Full record

ReviewNutrients2025

Chewing Matters: Masticatory Function, Oral Microbiota, and Gut Health in the Nutritional Management of Aging.

Monia Lettieri, Alessio Rosa, Fabrizio Spataro, Giovanni Capria, Paolo Barnaba, Marco Gargari, Mirko Martelli

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. [Aging-Associated Oral Microbiota Dysbiosis and Hypofunction: Their Role in Alzheimer's Disease Pathogenesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Oral Health and Risk of Malnutrition in Older Adults: A Systematic Review and Meta-analysis.Journal of International Society of Preventive & Community Dentistry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Monia LettieriSection of Hygiene, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00136 Rome, Italy.
Alessio RosaDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.ORCID 0009-0005-7972-8954
Fabrizio SpataroSection of Clinical Nutrition and Nutrigenomics, University of Rome Tor Vergata, 00133 Rome, Italy.
Giovanni CapriaSSD Centre for Artificial Nutrition, Antonio Cardarelli Regional Hospital, 80131 Campobasso, Italy.
Paolo BarnabaSection of Hygiene, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00136 Rome, Italy.ORCID 0000-0003-1349-7792
Marco GargariSection of Hygiene, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00136 Rome, Italy.
Mirko MartelliSection of Hygiene, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, 00136 Rome, Italy.ORCID 0000-0003-0039-0750

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is a multifactorial process that affects various physiological functions, including masticatory performance, which is crucial for oral health and nutritional well-being. Impaired masticatory function, often due to factors such as tooth loss, reduced salivation, or muscle atrophy, can lead to significant nutritional challenges and compromise the overall health of elderly individuals. Recent research has illuminated the interconnectedness of masticatory function, oral microbiota, and gut health, suggesting that altered chewing ability may disrupt oral microbial communities, which in turn affect gastrointestinal health and systemic inflammation. This commentary review provides a comprehensive analysis of the role of masticatory function in aging, exploring its impact on the oral microbiota, gut health, and broader nutritional status. We discuss the potential consequences of impaired mastication, including malnutrition, dysbiosis, and gastrointestinal disorders, and explore possible strategies for improving masticatory function and maintaining a healthy gut microbiome through interventions like dietary modifications, oral care, and rehabilitation. We aim to underscore the importance of integrating masticatory function management into the broader context of aging-related healthcare, promoting holistic, multidisciplinary approaches to support nutritional needs and quality of life in older adults.

Indexed as

AgingGastrointestinal MicrobiomeMasticationMicrobiotaMouthOral HealthAgedDysbiosisHumansMalnutritionNutritional Statusaging and nutritiongut healthmalnutrition in the elderlymasticatory functionoral microbiota

Identifiers

PMID40806092
PMCPMC12348602

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.