Evidence map›Paper›PMID 40806149›Full record

Trial reportNutrients2025

Long-Term Outcomes of the Dietary Approaches to Stop Hypertension (DASH) Intervention in Nonobstructive Coronary Artery Disease: Follow-Up of the DISCO-CT Study.

Magdalena Makarewicz-Wujec, Jan Henzel, Cezary Kępka, Mariusz Kruk, Barbara Jakubczak, Aleksandra Wróbel, Rafał Dąbrowski, Zofia Dzielińska, Marcin Demkow, Edyta Czepielewska and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Magdalena Makarewicz-WujecInstitute of Pharmaceutical Care, VIZJA University, Okopowa Street 59, 01-043 Warsaw, Poland.ORCID 0000-0002-4330-3007
Jan HenzelDepartment of Coronary and Structural Heart Diseases, National Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.ORCID 0000-0002-9619-2718
Cezary KępkaDepartment of Coronary and Structural Heart Diseases, National Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
Mariusz KrukDepartment of Coronary and Structural Heart Diseases, National Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
Barbara JakubczakMedical Diagnostic Laboratory, National Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
Aleksandra WróbelMedical Diagnostic Laboratory, National Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
Rafał DąbrowskiDepartment of Coronary Artery Disease and Cardiac Rehabilitation, National Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
Zofia DzielińskaDepartment of Coronary and Structural Heart Diseases, National Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
Marcin DemkowDepartment of Coronary and Structural Heart Diseases, National Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
Edyta CzepielewskaInstitute of Pharmaceutical Care, VIZJA University, Okopowa Street 59, 01-043 Warsaw, Poland.ORCID 0000-0002-3149-239X
Agnieszka FilipekDepartment of Pharmaceutical Biology, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.ORCID 0000-0002-1351-3687

Funding

Institute of Cardiology in Warsaw, Poland. 2.15/III/15
6 · The paper itself

Abstract

In the original randomised Dietary Intervention to Stop Coronary Atherosclerosis (DISCO-CT) trial, a 12-month Dietary Approaches to Stop Hypertension (DASH) project led by dietitians improved cardiovascular and metabolic risk factors and reduced platelet chemokine levels in patients with coronary artery disease (CAD). It is unclear whether these benefits are sustained.

objectiveTo determine whether the metabolic, inflammatory, and clinical benefits achieved during the DISCO-CT trial are sustained six years after the structured intervention ended.

methodsNinety-seven adults with non-obstructive CAD confirmed in coronary computed tomography angiography were randomly assigned to receive optimal medical therapy (control group,

resultsDuring the intervention, the DASH group lost an average of 3.6 ± 4.2 kg and reduced their total body fat by an average of 4.2 ± 4.8 kg, compared to an average loss of 1.1 ± 2.9 kg and a reduction in total body fat of 0.3 ± 4.1 kg in the control group (both

conclusionsA one-year DASH project supported by a physician and dietitian resulted in long-term suppression of the proatherogenic chemokine CXCL4 and fewer MACE over six years, despite a decline in adherence and loss of most anthropometric and lipid benefits. It appears that sustained systemic reinforcement of behaviours is necessary to maintain the benefits of lifestyle intervention in CAD.

Indexed as

Coronary Artery DiseaseDietary Approaches To Stop HypertensionHypertensionAdultAgedBody CompositionFemaleFollow-Up StudiesHumansMaleMiddle AgedTreatment Outcomechemokines CXCL4 and RANTEScoronary artery diseasesDASH diet

Identifiers

PMID40806149
PMCPMC12348568

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.