Evidence map›Paper›PMID 40806280›Full record

ArticleInternational journal of molecular sciences2025

CCR4-NOT Transcription Complex Subunit 7 (CNOT7) Protein and Leukocyte-Associated Immunoglobulin-like Receptor-1 in Breast Cancer Progression: Clinical Mechanistic Insights and In Silico Therapeutic Potential.

Mona M Elanany, Dina Mostafa, Ahmad A Hady, Mona Y Y Abd Allah, Nermin S Ahmed, Nehal H Elghazawy, Wolfgang Sippl, Tadashi Yamamoto, Nadia M Hamdy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mona M ElananyDepartment of Biochemistry, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.
Dina MostafaDepartment of Biochemistry, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.ORCID 0000-0002-9627-6372
Ahmad A HadyDepartment of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Mansoura University, Dakahlia, Mansoura 35516, Egypt.
Mona Y Y Abd AllahDepartment of Pathology, Faculty of Medicine, Mansoura University, New Cairo, Mansoura 35516, Egypt.
Nermin S AhmedDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo, Cairo 11835, Egypt.ORCID 0000-0002-8869-3387
Nehal H ElghazawyDepartment of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, 06120 Halle, Germany.ORCID 0000-0002-9376-5410
Wolfgang SipplDepartment of Medicinal Chemistry, Institute of Pharmacy, Martin-Luther-University of Halle-Wittenberg, 06120 Halle, Germany.ORCID 0000-0002-5985-9261
Tadashi YamamotoCell Signal Unit, Okinawa Institute of Science and Technology (OIST), Kunigami-gun, Okinawa 904-0495, Japan.
Nadia M HamdyDepartment of Biochemistry, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, Egypt.ORCID 0000-0003-2105-107X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastatic breast cancer (BC) spread underscores the need for novel prognostic biomarkers. This study investigated CCR4-NOT Transcription Complex Subunit 7 (CNOT7) and leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) in BC progression and natural killer (NK) cell resistance. In the current study, 90 female BC patients (46 non-metastatic, 44 metastatic) were analyzed. CNOT7 and LAIR-1 protein levels were measured in serum via ELISA and CNOT7 expression in tissue by immunohistochemistry (IHC). In silico tools explored related pathways. Computational analyses, including in silico bioinformatics and molecular docking, explored gene functions, interactions, and ligand binding to CNOT7 and LAIR-1. CNOT7 serum levels were significantly elevated in metastatic patients (mean 4.710) versus non-metastatic patients (mean 3.229,

Indexed as

Breast NeoplasmsReceptors, ImmunologicAdultAgedBiomarkers, TumorDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansKiller Cells, NaturalMiddle AgedMolecular Docking SimulationPrognosisSignal TransductionBiomarkers, Tumorleukocyte-associated immunoglobulin-like receptor 1Receptors, ImmunologicCNOT7in silico/bioinformatics analysisLAIR-1metastatic breast cancermolecular dockingnatural killer cell resistance

Identifiers

PMID40806280
PMCPMC12346410

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.