Evidence map›Paper›PMID 40806299›Full record

ArticleInternational journal of molecular sciences2025

A Genetically-Engineered Thyroid Gland Built for Selective Triiodothyronine Secretion.

Cintia E Citterio, Berenice Morales-Rodriguez, Xiao-Hui Liao, Catherine Vu, Rachel Nguyen, Jessie Tsai, Jennifer Le, Ibrahim Metawea, Ming Liu, David P Olson and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Thyroid Hormone Synthesis Without Thyroglobulin.Thyroid : official journal of the American Thyroid Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cintia E CitterioDepartment of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA.ORCID 0000-0002-3547-5458
Berenice Morales-RodriguezDepartment of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA.
Xiao-Hui LiaoDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Catherine VuDepartment of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA.ORCID 0009-0001-8410-5584
Rachel NguyenDepartment of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA.
Jessie TsaiDepartment of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA.
Jennifer LeDepartment of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA 92618, USA.
Ibrahim MetaweaDivision of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Ming LiuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Tianjin Medical University General Hospital, Tianjin 300052, China.
David P OlsonDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Samuel RefetoffDepartment of Medicine and Pediatrics and Committees on Genetics, The University of Chicago, Chicago, IL 60637, USA.
Peter ArvanDivision of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4007-8799

Funding

THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERSR01DK015070 · NIDDK · UNIVERSITY OF CHICAGO · 1986 to 2025
$4.1M
The Role of Thyroglobulin in Thyroid Hormone SynthesisK01DK125448 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 to 2025
$496k
Endoplasmic Reticulum stress and thyroid cell deathR01DK132017 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2025 to 2025
$390k
NIDDK NIH HHS K01 DK125448NIDDK NIH HHS R01 DK015070NIDDK NIH HHS R01 DK132017NIH HHS DK125448 (to C.E.C.)NIH HHS R01-DK132017 (to P. A.)
6 · The paper itself

Abstract

Thyroid hormones (thyroxine, T

Indexed as

Genetic EngineeringThyroid GlandTriiodothyronineAnimalsCRISPR-Cas SystemsGene Knock-In TechniquesHumansHypothyroidismMiceThyroglobulinThyrotropinThyroxineThyroglobulinThyrotropinThyroxineTriiodothyroninethyroglobulinthyroidthyroid hormonestriiodothyronine

Identifiers

PMID40806299
PMCPMC12346460

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.