Evidence map›Paper›PMID 40806321›Full record

ArticleInternational journal of molecular sciences2025

Site-Specific Gut Microbiome Changes After Roux-en-Y Gastric Bypass in Rats: Effects of a Multicomponent Bovine Colostrum-Based Complex.

Zhanagul Khassenbekova, Kadyrzhan Makangali, Aruzhan Shoman, Assem Sagandyk, Nurislam Mukhanbetzhanov, Farkhad Tarikhov, Timur Fazylov, Ylham Annaorazov, Elizaveta Vinogradova, Samat Kozhakhmetov and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhanagul KhassenbekovaInnovative Center ArtScience, Astana Z00T3X6, Kazakhstan.
Kadyrzhan MakangaliDepartment of Technology of Food and Processing Industry, S. Seifullin Kazakh Agrotechnical Research University, Astana Z11F9K5, Kazakhstan.ORCID 0000-0003-4128-6482
Aruzhan ShomanDepartment of Technology of Food and Processing Industry, S. Seifullin Kazakh Agrotechnical Research University, Astana Z11F9K5, Kazakhstan.
Assem SagandykDepartment of Technology of Food and Processing Industry, S. Seifullin Kazakh Agrotechnical Research University, Astana Z11F9K5, Kazakhstan.ORCID 0000-0001-5480-933X
Nurislam MukhanbetzhanovInnovative Center ArtScience, Astana Z00T3X6, Kazakhstan.
Farkhad TarikhovLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.ORCID 0000-0001-6246-4431
Timur FazylovInnovative Center ArtScience, Astana Z00T3X6, Kazakhstan.
Ylham AnnaorazovInnovative Center ArtScience, Astana Z00T3X6, Kazakhstan.ORCID 0000-0003-2037-1100
Elizaveta VinogradovaLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.ORCID 0009-0003-1845-2726
Samat KozhakhmetovLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.ORCID 0000-0001-9668-0327
Almagul KushugulovaLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.ORCID 0000-0001-9479-0899

Funding

Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan, Ministry of Agriculture of the Republic of Kazakhstan BR21882184, BR22883587
6 · The paper itself

Abstract

Roux-en-Y gastric bypass (RYGB) surgery induces profound gut microbiota alterations that may impact metabolic outcomes. This study investigated site-specific effects of a multicomponent bovine colostrum-honey-serviceberry (CHJ) complex on post-RYGB microbiome changes in obese rats. Twenty-nine Wistar rats underwent RYGB surgery with CHJ supplementation, followed by mucosal-associated microbiota analysis from five gastrointestinal segments using 16S rRNA sequencing and serum metabolite profiling. RYGB caused regional-specific changes: decreased alpha diversity, systematic

Indexed as

ColostrumGastric BypassGastrointestinal MicrobiomeAnimalsCattleDietary SupplementsDysbiosisMaleObesityRatsRats, WistarRNA, Ribosomal, 16SRNA, Ribosomal, 16Sbariatric surgerybovine colostrumdysbiosisEnterobacteriaceaegut microbiomemetabolic syndromeRoux-en-Y gastric bypassSCFA-producing bacteriasite specificity

Identifiers

PMID40806321
PMCPMC12347457

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.