Evidence map›Paper›PMID 40806549›Full record

ArticleInternational journal of molecular sciences2025

Assessing Determinants of Response to PARP Inhibition in Germline

Eleonora Allavena, Michela Croce, Bruna Dalmasso, Cecilia Profumo, Valentina Rigo, Virginia Andreotti, Irene Vanni, Benedetta Pellegrino, Antonino Musolino, Nicoletta Campanini and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Eleonora AllavenaDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0001-9214-4279
Michela CroceBiotherapies, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0000-0003-4683-4951
Bruna DalmassoCancer Genetics, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0002-1534-0521
Cecilia ProfumoBiotherapies, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0009-0004-8962-6487
Valentina RigoBiotherapies, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.
Virginia AndreottiCancer Genetics, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0002-2569-0832
Irene VanniCancer Genetics, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.ORCID 0000-0001-5900-4880
Benedetta PellegrinoMedical Oncology and Breast Unit, University Hospital of Parma, 43126 Parma, Italy.
Antonino MusolinoMedical Oncology, Breast & GYN Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.ORCID 0000-0002-7979-6261
Nicoletta CampaniniUnit of Pathological Anatomy, Department of Medicine and Surgery, University Hospital of Parma, 43126 Parma, Italy.
William BrunoDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-0337-0168
Luca MastracciAnatomic Pathology, Department of Surgical Sciences and Integrated Diagnostics, University of Genova, 16132 Genoa, Italy.ORCID 0000-0003-0193-5281
Gabriele ZoppoliDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-1619-1708
Enrica Teresa TandaSkin Cancer Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.
Francesco SpagnoloSkin Cancer Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.
Paola GhiorzoDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-3651-8173
Lorenza PastorinoDepartment of Internal Medicine and Medical Specialties, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-2575-8331

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ataxia-telangiectasia-mutated (ATM) protein plays a crucial role in the DNA damage response, particularly in the homologous recombination (HR) pathway. This study aimed to assess the impact of deleterious

Indexed as

Ataxia Telangiectasia Mutated ProteinsGerm-Line MutationMelanomaPoly(ADP-ribose) Polymerase InhibitorsCell Line, TumorDNA MethylationDrug Resistance, NeoplasmHumansNuclear ProteinsAtaxia Telangiectasia Mutated ProteinsATM protein, humanNuclear ProteinsPoly(ADP-ribose) Polymerase InhibitorsSLFN11 protein, humanATMgermline variationHRDmelanomaPARPi

Identifiers

PMID40806549
PMCPMC12346925

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.