Evidence map›Paper›PMID 40806580›Full record

ArticleInternational journal of molecular sciences2025

Polymorphic Variants of Selected Genes Regulating Bile Acid Homeostasis in Women with Intrahepatic Cholestasis of Pregnancy.

Krzysztof Piątek, Grażyna Kurzawińska, Marcin Ożarowski, Piotr Józef Olbromski, Adam Kamiński, Maciej Brązert, Tomasz M Karpiński, Wiesław Markwitz, Agnieszka Seremak-Mrozikiewicz

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Krzysztof PiątekDepartment of Gynecology and Obstetrics, University of Zielona Gora, Licealna 9, 65-417 Zielona Gora, Poland.
Grażyna KurzawińskaLaboratory of Molecular Biology, Department of Perinatology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.ORCID 0000-0002-8986-7772
Marcin OżarowskiDepartment of Biotechnology, Institute of Natural Fibres and Medicinal Plants-National Research Institute, Wojska Polskiego 71B, 60-630 Poznan, Poland.ORCID 0000-0003-2305-3116
Piotr Józef OlbromskiClinic of Operational Gynecology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.ORCID 0009-0007-7919-5005
Adam KamińskiDepartment of Orthopedics and Traumatology, Independent Public Clinical Hospital No. 1, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.
Maciej BrązertDepartment of Diagnostics and Treatment of Infertility, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.ORCID 0000-0002-2423-8238
Tomasz M KarpińskiChair and Department of Medical Microbiology, Poznan University of Medical Sciences, Rokietnicka 10, 60-806 Poznań, Poland.ORCID 0000-0001-6599-9204
Wiesław MarkwitzDepartment of Perinatology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.
Agnieszka Seremak-MrozikiewiczLaboratory of Molecular Biology, Department of Perinatology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is characterized by the onset of pruritus and elevated serum transaminases and bile acids (BA). The key enzyme in BA synthesis is CYP7A1, and its functions are regulated by various nuclear receptors. The goal of this study is to evaluate the association between

Indexed as

Bile Acids and SaltsCholestasis, IntrahepaticCholesterol 7-alpha-HydroxylaseHomeostasisPolymorphism, Single NucleotidePregnancy ComplicationsAdultAllelesCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansPPAR alphaPregnancyReceptors, Cytoplasmic and NuclearBile Acids and SaltsCholesterol 7-alpha-HydroxylaseCYP7A1 protein, humanPPAR alphaPPARA protein, humanReceptors, Cytoplasmic and NuclearRetinoid X Receptor alphagenes regulating bile acid homeostasisintrahepatic cholestasispolymorphic variantspregnancy

Identifiers

PMID40806580
PMCPMC12347146

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.