Evidence map›Paper›PMID 40806589›Full record

ArticleInternational journal of molecular sciences2025

Metabolic Dysfunction-Associated Steatotic Liver Disease Is Characterized by Enhanced Endogenous Cholesterol Synthesis and Impaired Synthesis/Absorption Balance.

Irena Frankovic, Aleksandra Zeljkovic, Ivana Djuricic, Ana Ninic, Jelena Vekic, Minja Derikonjic, Sanja Erceg, Ratko Tomasevic, Milica Mamic, Milos Mitrovic and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Irena FrankovicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.
Aleksandra ZeljkovicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0001-6417-8404
Ivana DjuricicDepartment of Bromatology, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-0539-4585
Ana NinicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-3838-1606
Jelena VekicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.
Minja DerikonjicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0009-0008-9677-4073
Sanja ErcegDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-7229-9406
Ratko TomasevicDepartment of Internal Medicine, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Milica MamicDepartment of Laboratory Diagnostics, Clinical Hospital Center Zemun, 11080 Belgrade, Serbia.
Milos MitrovicClinical Department for Gastroenterology and Hepatology, University Medical Center Zvezdara, 11120 Belgrade, Serbia.ORCID 0000-0003-4150-3707
Tamara GojkovicDepartment of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia.

Funding

Ministry of Science, Technological Development and Innovation, Republic of Serbia No 451-03-136/2025-03/ 200161 and No 451-03-137/2025-03/ 200161
6 · The paper itself

Abstract

Cholesterol accumulation plays a significant role in the pathogenesis of metabolic-dysfunction-associated steatotic liver disease (MASLD), yet changes in cholesterol homeostasis in MASLD remain insufficiently investigated. This study aimed to examine alterations in cholesterol synthesis and absorption by measuring plasma levels of endogenous cholesterol precursors (as markers of synthesis) and phytosterols (as indicators of absorption). A total of 124 MASLD patients and 43 healthy individuals were included. Our results showed higher plasma concentrations of lathosterol in the MASLD group (

Indexed as

CholesterolFatty LiverAdultBiomarkersCase-Control StudiesDesmosterolFemaleHumansMaleMiddle AgedPhytosterolsBiomarkersCholesterolDesmosterollathosterolPhytosterolscholesterol homeostasisdietary cholesterol absorptionendogenous cholesterol synthesishepatic steatosis indicesMASLDnon-cholesterol sterols

Identifiers

PMID40806589
PMCPMC12347333

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.