Evidence map›Paper›PMID 40806660›Full record

Observational studyInternational journal of molecular sciences2025

Early Effect of Supplementation with Essential Amino Acids on Cardiac Performance in Elderly Patients with Heart Failure and Sarcopenia.

Giuseppe Armentaro, Velia Cassano, Pasquale Loiacono, Carlo Fuoco, Giandomenico Severini, Carlo Alberto Pastura, Alberto Panza, Marilisa Panza, Elisa Mazza, Sofia Miceli and 3 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giuseppe ArmentaroGeriatrics Division, "Renato Dulbecco" University Hospital of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0001-9775-9715
Velia CassanoDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0002-0793-1225
Pasquale LoiaconoDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy.
Carlo FuocoDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy.
Giandomenico SeveriniDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy.ORCID 0009-0003-0136-4594
Carlo Alberto PasturaDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy.
Alberto PanzaDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy.
Marilisa PanzaDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy.
Elisa MazzaDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0003-3198-7090
Sofia MiceliGeriatrics Division, "Renato Dulbecco" University Hospital of Catanzaro, 88100 Catanzaro, Italy.
Arturo PujiaDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy.
Tiziana MontalciniResearch Center for the Prevention and Treatment of Metabolic Diseases, University Magna Græcia, 88100 Catanzaro, Italy.ORCID 0000-0001-7048-5830
Angela SciacquaGeriatrics Division, "Renato Dulbecco" University Hospital of Catanzaro, 88100 Catanzaro, Italy.ORCID 0000-0003-1674-5317

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present observational study was to evaluate the early effect of free-form essential amino acid (EAA) supplementation on cardiac and muscular performance in elderly patients with chronic heart failure (HF) with reduced ejection fraction (HFrEF) and sarcopenia, as add-on to the optimized medical therapy (OMT) for HF. The present study included 60 elderly Caucasian patients suffering from HFrEF and sarcopenia. At the baseline and at follow-up, all patients underwent complete physical examination with the determination of the main anthropometric and hemodynamic parameters. After 6 months of supplementation with EAAs, we observed significant improvements in the parameters of sarcopenia. In addition, there was a significant improvement in glycol-metabolic parameters, and in inflammatory index as high sensitivity C-reactive protein (hs-CRP). In accordance with these results, significant decreases were observed in circulating levels of oxidative stress biomarkers Nox-2 (

Indexed as

Amino Acids, EssentialDietary SupplementsHeart FailureSarcopeniaAgedAged, 80 and overBiomarkersFemaleHumansMaleOxidative StressStroke VolumeAmino Acids, EssentialBiomarkersessential amino acidsheart failureoxidative stresssarcopenia

Identifiers

PMID40806660
PMCPMC12346981

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.