Evidence map›Paper›PMID 40807097›Full record

ReviewJournal of clinical medicine2025

Efficacy and Safety of Intravenous Thrombolysis in the Extended Time Window for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.

Lina Palaiodimou, Nikolaos M Papageorgiou, Apostolos Safouris, Aikaterini Theodorou, Eleni Bakola, Maria Chondrogianni, Georgia Papagiannopoulou, Odysseas Kargiotis, Klearchos Psychogios, Eftihia Polyzogopoulou and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Time is brain: an expanded concept, not only for ischemic stroke A viewpoint of the Italian Association for Emergency Neurology (ANEU).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lina PalaiodimouSecond Department of Neurology, "Attikon" University Hospital, School of Medicine, National & Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece.ORCID 0000-0001-7757-609X
Nikolaos M PapageorgiouSecond Department of Neurology, "Attikon" University Hospital, School of Medicine, National & Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece.ORCID 0000-0002-1077-8970
Apostolos SafourisSecond Department of Neurology, "Attikon" University Hospital, School of Medicine, National & Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece.ORCID 0000-0002-9630-6949
Aikaterini TheodorouSecond Department of Neurology, "Attikon" University Hospital, School of Medicine, National & Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece.ORCID 0000-0001-7229-2610
Eleni BakolaSecond Department of Neurology, "Attikon" University Hospital, School of Medicine, National & Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece.ORCID 0000-0002-7002-9795
Maria ChondrogianniSecond Department of Neurology, "Attikon" University Hospital, School of Medicine, National & Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece.ORCID 0000-0002-8315-5846
Georgia PapagiannopoulouSecond Department of Neurology, "Attikon" University Hospital, School of Medicine, National & Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece.ORCID 0000-0003-0052-5678
Odysseas KargiotisDepartment of Neurology, University General Hospital of Patras, University of Patras, 26504 Rio, Greece.ORCID 0000-0002-8317-6428
Klearchos PsychogiosStroke Unit, Metropolitan Hospital, 18547 Piraeus, Greece.ORCID 0000-0003-3993-2545
Eftihia PolyzogopoulouEmergency Medicine Clinic, "Attikon" University Hospital, School of Medicine, National & Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0001-7585-1203
Georgios MagoufisInterventional Radiology Unit, Second Department of Radiology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Georgios VelonakisSecond Department of Radiology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0002-0050-284X
Jobst RudolfDepartment of Neurology, Papageorgiou General Hospital, 56429 Thessaloniki, Greece.
Panayiotis MitsiasDepartment of Neurology, University General Hospital of Heraklion, School of Medicine, University of Crete, 71500 Heraklion, Greece.ORCID 0000-0002-9089-4954
Georgios TsivgoulisSecond Department of Neurology, "Attikon" University Hospital, School of Medicine, National & Kapodistrian University of Athens, Rimini 1, Chaidari, 12462 Athens, Greece.ORCID 0000-0002-0640-3797

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acute ischemic strokeextended-time windowfunctional outcomeintravenous thrombolysismeta-analysissymptomatic intracranial hemorrhage

Identifiers

PMID40807097
PMCPMC12347962

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.