Evidence map›Paper›PMID 40807253›Full record

ArticleMolecules (Basel, Switzerland)2025

Nanoceria Coated with Maltodextrin or Chitosan: Effects on Key Genes of Oxidative Metabolism, Proliferation, and Autophagy in Human Embryonic Lung Fibroblasts.

Elena V Proskurnina, Madina M Sozarukova, Elizaveta S Ershova, Ekaterina A Savinova, Larisa V Kameneva, Natalia N Veiko, Vladimir P Saprykin, Khamzat K Vyshegurov, Vladimir K Ivanov, Svetlana V Kostyuk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elena V ProskurninaKurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow 119071, Russia.ORCID 0000-0002-8243-6339
Madina M SozarukovaKurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow 119071, Russia.ORCID 0000-0002-5868-4746
Elizaveta S ErshovaState Scientific Center of the Russian Federation "Russian Scientific Center of Surgery Named After Academician B.V. Petrovsky", Institute of Longevity with a Clinic of Rehabilitation and Preventive Medicine, Moscow 119435, Russia.ORCID 0000-0003-1206-5832
Ekaterina A SavinovaDepartment of Biology and General Genetics, Institute of Medicine, Patrice Lumumba Peoples' Friendship University of Russia, Moscow 117198, Russia.ORCID 0000-0001-5286-516X
Larisa V KamenevaResearch Centre for Medical Genetics, Moscow 115522, Russia.
Natalia N VeikoState Scientific Center of the Russian Federation "Russian Scientific Center of Surgery Named After Academician B.V. Petrovsky", Institute of Longevity with a Clinic of Rehabilitation and Preventive Medicine, Moscow 119435, Russia.
Vladimir P SaprykinFaculty of Biotechnology and Fisheries, K.G. Razumovsky Moscow State University of Technologies and Management, Moscow 109004, Russia.ORCID 0000-0003-1140-808X
Khamzat K VyshegurovDepartment of Faculty Therapy of the Medical Institute, Ingush State University, Magas 386001, Russia.
Vladimir K IvanovKurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow 119071, Russia.ORCID 0000-0003-2343-2140
Svetlana V KostyukKurnakov Institute of General and Inorganic Chemistry of the Russian Academy of Sciences, Moscow 119071, Russia.

Funding

Russian Science Foundation 24-25-00088
6 · The paper itself

Abstract

Nanoceria is a multifaceted enzyme-like catalyst of ROS-mediated (reactive oxygen species) reactions, which results in its multiple biomedical applications. Biodegradable polysaccharide coatings improve biocompatibility, while the effects of these coatings on the ROS-related activity of nanoceria in cells need thorough studies. Here, we used human embryonic lung fibroblasts to study the effects of maltodextrin and chitosan coatings on cellular oxidative metabolism of nanoceria by examining cell viability, mitochondrial potential, accumulation of nanoparticles in cells, intracellular ROS, expression of NOX4 (NADPH oxidase 4), NRF2 (nuclear factor erythroid 2-related factor 2), NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), and STAT3 (signal transducer and activator of transcription 3) proteins as well as the expression of biomarkers of DNA damage/repair, cell proliferation, and autophagy. Both types of polysaccharide-coated nanoceria were non-toxic up to millimolar concentrations. For maltodextrin-coated nano-CeO

Indexed as

AutophagyCeriumChitosanFibroblastsLungPolysaccharidesCell ProliferationCell SurvivalHumansNanoparticlesNF-E2-Related Factor 2NF-kappa BOxidation-ReductionOxidative StressReactive Oxygen Speciesceric oxideCeriumChitosanmaltodextrinNF-E2-Related Factor 2NF-kappa BPolysaccharidesReactive Oxygen Speciesautophagychitosancytotoxicitygenotoxicitymaltodextrinnanoceriaoxidative metabolismproliferation

Identifiers

PMID40807253
PMCPMC12348771

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.