Evidence map›Paper›PMID 40807456›Full record

ArticleMolecules (Basel, Switzerland)2025

Inhibitory Impact of the Amino Benzoic Derivative DAB-2-28 on the Process of Epithelial-Mesenchymal Transition in Human Breast Cancer Cells.

Laurie Fortin, Julie Girouard, Yassine Oufqir, Alexis Paquin, Francis Cloutier, Isabelle Plante, Gervais Bérubé, Carlos Reyes-Moreno

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Bioactive spectrum of goji berries (Food chemistry: X · 2026
    Review
  2. Anti-Inflammatory Activity of Cyclic Imide Derivatives.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laurie FortinGroupe de Recherche en Signalisation Cellulaire (GRSC), Département de Biologie Médicale, Université du Québec à Trois-Rivières, Trois-Rivières, QC G8Z 4M3, Canada.ORCID 0000-0003-4550-6075
Julie GirouardGroupe de Recherche en Signalisation Cellulaire (GRSC), Département de Biologie Médicale, Université du Québec à Trois-Rivières, Trois-Rivières, QC G8Z 4M3, Canada.
Yassine OufqirGroupe de Recherche en Signalisation Cellulaire (GRSC), Département de Biologie Médicale, Université du Québec à Trois-Rivières, Trois-Rivières, QC G8Z 4M3, Canada.
Alexis PaquinRegroupement Intersectoriel de Recherche en Santé de l'Université du Québec (RISUQ), Université du Québec, Québec, QC G1K 9H7, Canada.ORCID 0000-0003-4714-2041
Francis CloutierRegroupement Intersectoriel de Recherche en Santé de l'Université du Québec (RISUQ), Université du Québec, Québec, QC G1K 9H7, Canada.
Isabelle PlanteRegroupement Intersectoriel de Recherche en Santé de l'Université du Québec (RISUQ), Université du Québec, Québec, QC G1K 9H7, Canada.ORCID 0000-0003-2080-6450
Gervais BérubéRegroupement Intersectoriel de Recherche en Santé de l'Université du Québec (RISUQ), Université du Québec, Québec, QC G1K 9H7, Canada.ORCID 0000-0001-8001-0150
Carlos Reyes-MorenoGroupe de Recherche en Signalisation Cellulaire (GRSC), Département de Biologie Médicale, Université du Québec à Trois-Rivières, Trois-Rivières, QC G8Z 4M3, Canada.ORCID 0000-0002-4665-7070

Funding

Cancer Research Society and the Canadian Institutes of Health Research CRS: number 22471; CIHR; number 392334
6 · The paper itself

Abstract

Macrophage-mediated inflammation is known to be involved in the epithelial-mesenchymal transition (EMT) of various types of cancer. This makes macrophage-derived inflammatory factors prime targets for the development of new treatments. This study uncovers the therapeutic potential and action mechanism of DAB-2-28, a small-molecule derived from

Indexed as

Antineoplastic AgentsBreast NeoplasmsEpithelial-Mesenchymal TransitionCadherinsCell Line, TumorCell MovementCulture Media, ConditionedFemaleGene Expression Regulation, NeoplasticHumansMacrophagesMatrix Metalloproteinase 9MCF-7 CellsSignal TransductionSnail Family Transcription FactorsAntineoplastic AgentsCadherinsCulture Media, ConditionedMatrix Metalloproteinase 9Snail Family Transcription Factorsinflammationluminal breast cancermacrophagespara-aminobenzoic acid (PABA)small moleculestriple-negative breast cancer

Identifiers

PMID40807456
PMCPMC12348098

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.