Evidence map›Paper›PMID 40807476›Full record

ArticleMolecules (Basel, Switzerland)2025

Synthesis and Biological Activity of Novel Polyazaheterocyclic Derivatives of Quinine.

Gulim K Mukusheva, Nurizat N Toigambekova, Roza B Seidakhmetova, Roza I Jalmakhanbetova, Mukhlissa N Babakhanova, Oralgazy A Nurkenov, Ekaterina A Akishina, Evgenij A Dikusar, Irina A Kolesnik, Hongwei Zhou and 1 more

Abstract read
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In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gulim K MukushevaChemistry Faculty, Karaganda Buketov University, Karaganda 100024, Kazakhstan.
Nurizat N ToigambekovaChemistry Faculty, Karaganda Buketov University, Karaganda 100024, Kazakhstan.
Roza B SeidakhmetovaDepartment of Clinical Pharmacology and Evidence-Based Medicine, Karaganda Medical University, Karaganda 100024, Kazakhstan.
Roza I JalmakhanbetovaFaculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan.ORCID 0000-0001-9937-275X
Mukhlissa N BabakhanovaFaculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan.
Oralgazy A NurkenovInstitute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, Kazakhstan.ORCID 0000-0003-1878-2787
Ekaterina A AkishinaInstitute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.ORCID 0000-0002-0803-8623
Evgenij A DikusarInstitute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
Irina A KolesnikInstitute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.
Hongwei ZhouCollege of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China.ORCID 0000-0001-8308-960X
Vladimir I PotkinInstitute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus.

Funding

This research has been funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan. AP19674667
6 · The paper itself

Abstract

A synthetic methodology of the CuAAC "click" approach was exploited for the construction of 1,2-azolyltriazole quinine derivatives by the reaction of O-propargylquinine with azidomethyl-1,2-azoles in methanol. Quinine-piperidine and quinine-anabasine conjugates were obtained using a chloroacetate linker by reacting quinine chloroacetate with piperidine or anabasine in a diethyl ether medium. Cinchophene ester was obtained by the acylation of quinine with cinchophen acid chloride in methylene chloride. The antibacterial, fungicidal, analgesic and cytotoxic properties of the obtained compounds were examined.

Indexed as

QuinineAnalgesicsAnimalsAnti-Bacterial AgentsAntifungal AgentsClick ChemistryHumansMicrobial Sensitivity TestsMolecular StructurePiperidinesAnalgesicsAnti-Bacterial AgentsAntifungal AgentsPiperidinesQuinineanabasineazide-alkyne cycloadditioncinchophenestersisothiazoleisoxazolemethyl iodidesquininetriazole

Identifiers

PMID40807476
PMCPMC12348970

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.