Evidence map›Paper›PMID 40808164›Full record

ArticlePolymers2025

Red Cabbage Anthocyanin-Loaded Bacterial Cellulose Hydrogel for Colorimetric Detection of Microbial Contamination and Skin Healing Applications.

Hanna Melnyk, Olesia Havryliuk, Iryna Zaets, Tetyana Sergeyeva, Ganna Zubova, Valeriia Korovina, Maria Scherbyna, Lilia Savinska, Lyudmila Khirunenko, Evzen Amler and 4 more

Abstract read
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hanna MelnykInstitute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150, Zabolotnogo Str., 03143 Kyiv, Ukraine.ORCID 0000-0002-6442-1168
Olesia HavryliukDepartment of Extremophilic Microorganisms Biology, D. K. Zabolotny Institute of Microbiology and Virology of the National Academy of Sciences of Ukraine, 154 Zabolotnogo Str., 03143 Kyiv, Ukraine.ORCID 0000-0003-2815-3976
Iryna ZaetsInstitute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150, Zabolotnogo Str., 03143 Kyiv, Ukraine.
Tetyana SergeyevaInstitute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150, Zabolotnogo Str., 03143 Kyiv, Ukraine.ORCID 0000-0003-3486-2701
Ganna ZubovaInstitute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150, Zabolotnogo Str., 03143 Kyiv, Ukraine.
Valeriia KorovinaInstitute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150, Zabolotnogo Str., 03143 Kyiv, Ukraine.
Maria ScherbynaInstitute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150, Zabolotnogo Str., 03143 Kyiv, Ukraine.
Lilia SavinskaInstitute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150, Zabolotnogo Str., 03143 Kyiv, Ukraine.ORCID 0009-0001-0658-0101
Lyudmila KhirunenkoInstitute of Physics, National Academy of Sciences of Ukraine, 46 Nauky Ave., 03680 Kyiv, Ukraine.
Evzen AmlerStudent Science, s.r.o., č.p. 237, 407 57 Horní Podluží, Czech Republic.
Maria BardosovaInstitute of Informatics, Slovak Academy of Science, Dúbravská Str. 9, 84507 Bratislava, Slovakia.
Oleksandr GorbachNational Cancer Institute of Ukraine, 33/43, Lomonosova Str., 03022 Kyiv, Ukraine.
Sergiy RogalskyV.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Acad. Kukhar Str. 1, 02094 Kyiv, Ukraine.ORCID 0000-0002-5200-5247
Natalia KozyrovskaInstitute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150, Zabolotnogo Str., 03143 Kyiv, Ukraine.

Funding

Smart Wound Monitoring Restorative Dressings (SWORD) H2020-MSCA-RISE-2019-873123
6 · The paper itself

Abstract

Developing innovative, low-cost halochromic materials for diagnosing microbial contamination in wounds and burns can effectively facilitate tissue regeneration. Here, we combine the pH-sensing capability of highly colorful red cabbage anthocyanins (RCAs) with their healing potential within a unique cellulose polymer film that mimics the skin matrix. Biological activities of RCA extract in bacterial cellulose (BC) showed no cytotoxicity and skin-sensitizing potential to human cells at concentrations of RCAs similar to those released from BC/RCA dressings (4.0-40.0 µg/mL). A decrease in cell viability and apoptosis was observed in human cancer cells with RCAs. The invisible eye detection of the early color change signal from RCAs in response to pH alteration by bacteria was recorded with a smartphone application. The incorporation of RCAs into BC polymer has altered the morphology of its matrix, resulting in a denser cellulose microfibril network. The complete coincidence of the vibrational modes detected in the absorption spectra of the cellulose/RCA composite with the modes in RCAs most likely indicates that RCAs retain their structure in the BC matrix. Affordable, sensitive halochromic BC/RCA hydrogels can be recommended for online monitoring of microbial contamination, making them accessible to patients.

Indexed as

bacterial cellulosehalochromic pH sensorred cabbage anthocyanins

Identifiers

PMID40808164
PMCPMC12349152

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.