ArticleNeural regeneration research2026
Therapeutic mechanisms of umbilical cord mesenchymal stem cell-derived exosomes in ischemic stroke: A transcriptomic and metabolomic study.
Article in Neural regeneration research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Bone marrow mesenchymal stem cells protect against cerebral amyloid angiopathy by enhancing neutrophil mitocytosis.Neural regeneration research · 2026Article
- Evolution of neutrophil extracellular traps in the pathology of stroke.Neural regeneration research · 2026Article
- Human adipose stem cell-derived exosomes modulate the transcriptome of D-galactose-Induced neuronal cells.Scientific reports · 2026Article
- Engineered Exosomal miRNAs for Post-Stroke Neural Repair: Mechanisms, Delivery Strategies, and Translational Challenges.International journal of nanomedicine · 2026Review
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
JOURNAL/nrgr/04.03/01300535-202606000-00078/figure1/v/2026-02-11T151048Z/r/image-tiff Ischemic stroke remains a leading cause of disability and death, with mesenchymal stem cell-derived exosomes emerging as a promising therapeutic avenue. However, the optimal timing and underlying therapeutic mechanisms of exosome treatment require further elucidation. In this study, we used a murine model of middle cerebral artery occlusion to investigate the therapeutic efficacy of human umbilical cord mesenchymal stem cell-derived exosomes administered intravenously at an early (6 hours) or delayed (3 days) time point post-ischemia. Compared with delayed treatment, early administration of exosomes resulted in significantly superior efficacy, as evidenced by improved neurological function scores and reduced infarct volumes. Transcriptomic analysis of brain tissues from mice receiving early exosome treatment revealed marked downregulation of inflammation-related genes, including Ccl2 , Ccl5 , Cxcl10 , Il-1 β, Il-6 , Itgam , Itgax , and Tnf-α . Metabolomic profiling of these brain tissues further identified modulation of key metabolites, including trimethylamine N-oxide, glutathione, 1-stearoyl-rac-glycerol, and phosphatidylcholine, suggesting that alteration of metabolic pathways contributes to the therapeutic effect. Integrated transcriptomic and metabolomic analysis pinpointed significant modulation of pathways involving metabolism of eicosapentaenoic acid, lysine, propanoate, and tyrosine. These findings suggest that umbilical cord mesenchymal stem cell-derived exosomes, particularly when administered early post-ischemia, exert their neuroprotective effects by broadly suppressing inflammatory pathways and modulating key metabolic processes in the ischemic brain, highlighting their potential as a therapeutic intervention for ischemic stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.