ArticleAnimal bioscience2026
Multiomics reveals changes in lipid metabolism in the livers of Landes geese before and after overfeeding.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- First Insights into Changes in the Gut Microbiota of Landes Geese Infected withAnimals : an open access journal from MDPI · 2026Article
- FABP4 regulates inflammation and lipid transport via PPARγ signaling pathway in goose primary hepatocytes.Poultry science · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveThe aim of this experiment was to integrate production indices with omics sequencing to elucidate the systemic perturbations between hepatic metabolism and the gut microbiota during overfeeding.
methodsA total of 120 seven-week-old male Landes geese were floor-reared in a pen environment. Overfeeding commenced at week 8 using a corn-based diet containing 5% soybean oil. The feeding regimen consisted of three daily meals (150-180 g/meal) initially, gradually increasing to five meals (300-500 g/meal) after two weeks, and was maintained for a total overfeeding period of four weeks.
resultsThe results demonstrated that overfeeding significantly increased liver weight and serum lipid levels, accompanied by intracellular lipid droplet accumulation. Concurrently, the downregulation of taurine-conjugated bile acids and the upregulation of free bile acids disrupted cholesterol homeostasis. Crucially, overfeeding triggered gut microbial dysbiosis characterized by Escherichia-Shigella enrichment and norank_o_Clostridia_UCG-014 depletion.
conclusionOur work demonstrated that the identification of the "gut microbiota‒bile acid‒liver axis" could serve as a pivotal signaling pathway driving overfeeding-induced foie gras formation while providing a theoretical foundation for overfeeding strategies to mitigate metabolic pathologies in waterfowl production.
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