Evidence map›Paper›PMID 40808630›Full record

ArticleEnvironmental science & technology2025

Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry.

Anna K Boatman, Jessie R Chappel, Kaylie I Kirkwood-Donelson, Jonathon F Fleming, David M Reif, Emma L Schymanski, Julia E Rager, Erin S Baker

Abstract read
In one paragraph

Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Anna K BoatmanDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, United States.ORCID 0000-0003-2582-0622
Jessie R ChappelDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, United States.ORCID 0009-0005-1492-118X
Kaylie I Kirkwood-DonelsonImmunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, United States.ORCID 0000-0003-3248-820X
Jonathon F FlemingPredictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Durham, North Carolina 27713, United States.
David M ReifPredictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Durham, North Carolina 27713, United States.
Emma L SchymanskiLuxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 6 Avenue du Swing, L-4367 Belvaux, Luxembourg.ORCID 0000-0001-6868-8145
Julia E RagerDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, United States.
Erin S BakerDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, United States.ORCID 0000-0001-5246-2213

Funding

The UNC Chapel Hill Superfund Research Program (UNC-SRP)P42ES031007 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kun Lu · 2020 to 2026
$22.2M
Single cell, multi-parametric high throughput platform to classify endocrine disruptor potential of mixturesP42ES027704 · NIEHS · TEXAS A&M UNIVERSITY · PI Thomas Joseph McDonald · 2017 to 2026
$21.2M
TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0M
NIEHS NIH HHS P42 ES027704NIEHS NIH HHS P42 ES031007NIEHS NIH HHS T32 ES007126
6 · The paper itself

Abstract

Over the past decade, global contamination from per- and polyfluoroalkyl substances (PFAS) has become apparent due to their detection in countless matrices worldwide, from consumer products to human blood to drinking water. As researchers implement nontargeted analyses (NTA) to more fully understand the PFAS present in the environment and human bodies, clear guidance is needed for consistent and objective reporting of the identified molecules. Confidence levels for small molecules analyzed and identified with high-resolution mass spectrometry (HRMS) have existed since 2014; however, unification of currently used levels and improved guidance for their application is needed due to inconsistencies in reporting and continuing innovations in analytical methods. Here, we (i) investigate current practices for confidence level reporting of PFAS identified with liquid chromatography (LC), gas chromatography (GC), and/or ion mobility spectrometry (IMS) coupled with HRMS and (ii) propose a simple, unified confidence level guidance that incorporates both PFAS-specific attributes and IMS collision cross section (CCS) values.

Indexed as

FluorocarbonsIon Mobility SpectrometryEnvironmental MonitoringHumansFluorocarbonshigh-resolution mass spectrometry (HRMS)identification confidenceion mobility spectrometry (IMS)nontargeted analysis (NTA)per- and polyfluoroalkyl substances (PFAS)

Identifiers

PMID40808630
PMCPMC12424050

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.