SynthesisFrontiers in neurology2025
Effectiveness of virtual reality for functional disorders in cerebral palsy: an overview of systematic reviews and meta-analyses.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of Virtual Reality Use on Children with Cerebral Palsy and Its Applications in Health: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Cerebral palsy (CP), a pediatric neuromotor disorder, profoundly impacts functional independence and participation. Virtual reality (VR) has developed as a potential neurorehabilitation tool, yet its therapeutic efficacy remains inconsistently validated. This overview aims to synthesize evidence from systematic reviews (SRs) and meta-analyses (MAs) to evaluate VR's effectiveness in CP rehabilitation. Methods: Systematic searches across ten databases-Embase, Web of Science, Cochrane Library, PubMed, CINAHL, JBI, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), China Bio-Medical Literature Service System (Sino-Med), and Wanfang Database-identified SRs/MAs on VR for CP from inception to November 10, 2024. The duplicate rate of primary studies was assessed by calculating the corrected covered area (CCA) through the establishment of a literature overlap matrix. Methodological rigor, reporting quality, bias risk, and evidence quality were appraised using the Assessment of Multiple Systematic Reviews 2 (AMSTAR-2), the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 (PRISMA2020), the Risk of Bias in Systematic Reviews (ROBIS), and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tools, respectively. Results: Sixteen SRs/MAs (5 low quality, 11 very low quality, according to AMSTAR-2) were included. The CCA was calculated as 0.135, indicating a high degree of overlap. PRISMA 2020 compliance revealed incomplete reporting in 37% of items. ROBIS indicated low bias risk in 13 studies. GRADE assessments classified 58 outcomes: 9 moderate (15.5%), 21 low (36.2%), and 28 very low (48.3%) quality. VR demonstrated clinical potential for improving motor function and activities of daily living (ADL), particularly in younger children with higher intervention dosages. However, heterogeneity in outcome measures, CP subtypes, and VR protocols limited generalizability. Conclusion: VR shows potential in improving motor dysfunction and ADL in CP. However, the included SRs/MAs typically exhibited low methodological and evidence quality. Therefore, caution must be taken when interpreting these findings. Moreover, high-quality randomized controlled trials and standardized VR protocols are urgently needed to establish evidence-based guidelines for CP rehabilitation. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024614631, CRD42024614631.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.