ArticleIranian journal of basic medical sciences2025
Sustained neutrophil infiltration and bacterial grain morphology underlie chronic mycetoma pathology in a murine model.
Article in Iranian journal of basic medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Mast Cells Control the Bacterial Burden and Grain Formation in Murine Experimental Actinomycetoma Induced byPathogens & immunity · 2026Article
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5 authors.
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Abstract
Objectives: This study aimed to characterize the progression of chronic mycetoma caused by Materials and Methods: BALB/c mice were inoculated with Results: Chronic mycetoma progression revealed stable bacterial burden and lesion volume stabilization after 70 dpi through 365 dpi. Systemic expansion of CD4+ T cells in the spleen and sustained neutrophil dominance (>90% infiltration) characterized chronic lesions. Progressive tissue necrosis and panniculitis, undetectable by external lesion size, emerged histologically. Serum IL-6 levels surged during chronicity, suggesting a Th17 polarization, contrasting with declining MCP-1. Bacterial grains transitioned from club-shaped to circular over time, suggesting structural grain remodeling. Conclusion: In chronic experimental mycetoma, the cell response is mainly characterized by neutrophil infiltration, an altered CD4+ T cell response, and dysregulated cytokine production. The shape of bacterial grains continues to change, and the bacterial load remains constant.
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