ArticleNutrition research and practice2025
Combination of intermittent fasting and endurance exercise impedes the development of the musculoskeletal system in non-obese growing rats.
Article in Nutrition research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe proliferation of appearance-centered values on social media has driven non-obese adolescents towards increasingly extreme diets and exercise programs to achieve weight loss. Despite this, the effects of concurrent diets and exercise on musculoskeletal development during adolescence are unclear. This study examined whether prolonged endurance exercise (EX) with intermittent fasting during adolescence adversely affects musculoskeletal growth. MATERIALS/
methodsEight-week-old male Sprague-Dawley rats were assigned to 1 of 4 groups: sedentary (SED), intermittent fasting (IF), EX (treadmill running), or a combination of IF and EX (IFEX) (n = 6 per group). The rats were treated for 8 weeks, and the food intake and body weight were measured weekly. After 8 weeks of treatment, the muscle and fat masses were measured, and the bone mineral content and mineral density were assessed using dual-energy X-ray absorptiometry. The mitochondrial and antioxidant enzymes, thiobarbituric acid reactive substances (TBARs), and factors related to protein synthesis and hydrolysis in skeletal muscle were also analyzed.
resultsThe IF and EX separately reduced the body weight, but the IFEX strategy also decreased skeletal muscle weight and bone mass. The protein levels associated with mitochondrial enzymes were significantly lower in the IFEX group. Moreover, elevated levels of skeletal muscle TBARs, forkhead box protein O1 phosphorylation, and the E3 ubiquitin ligases muscle atrophy F-box and muscle ring-finger protein-1 were observed.
conclusionEight weeks of IFEX treatment significantly impaired musculoskeletal development in healthy growing rats despite its intention to promote weight loss.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.