ArticleFrontiers in aging neuroscience2025
Mechanistic exploration of obesity-related indicators and motor cognitive risk syndrome: a mediated effect based on C-reactive protein triglyceride glucose index.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Evaluate the Risk Factors of Mild Cognitive Impairment (MCI) in Patients with Type 2 Diabetes Mellitus (T2DM): A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Body roundness index and adolescent metabolic syndrome: dose-response analysis and serum biomarker mediation.Frontiers in nutrition · 2026Article
- Association between fundus tessellated density and subfoveal choroidal thickness in children with different refractive statuses.Frontiers in medicine · 2026Article
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Authors and funding
4 authors.
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Abstract
Objective: To investigate the relationships between obesity-related indicators and motor cognitive risk syndrome (MCR), as well as the mediating role of the C-reactive protein triglyceride glucose index (CTI). Methods: The aim of this study was to provide evidence-based support to optimize MCR screening programs and develop prevention strategies for cognitive impairment in elderly individuals. This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) in 2015, and 5,665 participants were ultimately included. The independent variables were obesity-related indicators (WC, Waist circumference; WHtR, waist to height ratio; BRI, body roundness index; BMI, body mass index), and the mediating variable was CTI. Multiple logistic regression analysis, threshold effect analysis, and curve fitting analysis were used to analyze the relationships between obesity-related indicators and MCR. The mediation analysis method was used to observe the mediating effect of CTI. Results: BMI, WC, WHtR, and BRI all significantly increased the risk of MCR. Threshold analysis revealed a nonlinear BRI-MCR association (inflection point = 2.45, Conclusion: This study, which is based on CHARLS data, revealed that obesity-related indicators (WC, WHtR, BRI) significantly correlate with MCR risk. Metabolic disorders mediate the association of WHtR with MCR, confirming their central role in the link between obesity and cognition. Threshold effects were observed. The proposed method is to incorporate WHtR and CTI into community health assessments for early cognitive impairment screening, offering evidence for targeted interventions in resource-limited settings.
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