Predictive value of ferritin heavy chains in the development of coronary artery calcification in patients on maintenance hemodialysis: a prospective cohort study.

Sipei Chen, Yu Tang, Yangmei Pu, Xiaoqiang Xia, Yi Li, Yang Zou

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Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Iron in Vascular Calcification: Pro-Calcific Agent or Protective Modulator?International journal of molecular sciences · 2025
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sipei Chen *Department of Nephrology and Institute of Nephrology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan Clinical Research Centre for Kidney Diseases, Chengdu, Sichuan, China.

Yu Tang *Department of Nephrology and Institute of Nephrology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan Clinical Research Centre for Kidney Diseases, Chengdu, Sichuan, China.

Yangmei Pu *School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Xiaoqiang XiaState Key Laboratory of Oral Diseases, National Clinical Research, Center for Oral Diseases, Chinese Academy of Medical Sciences, Research Unit of Oral Carcinogenesis and Management, West China, Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Yi LiDepartment of Nephrology and Institute of Nephrology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan Clinical Research Centre for Kidney Diseases, Chengdu, Sichuan, China.

Yang ZouDepartment of Nephrology and Institute of Nephrology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Sichuan Clinical Research Centre for Kidney Diseases, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vascular calcification (VC) is a well-established risk factor for cardiovascular disease (CVD) and mortality in patients on maintenance hemodialysis (MHD). These patients frequently present with hyperphosphatemia as well as disorders of iron metabolism. This study aims to explore the role of ferritin heavy chain (FTH) in the development and progression of coronary artery calcification (CAC) in patients on MHD and assess its predictive value. Methods: Using a bioinformatics approach, we analyzed datasets related to VC. In our prospective study, we evaluated the Coronary Artery Calcification Score (CACS) alongside clinical markers, including serum FTH, serum ferritin, and transferrin saturation (TSAT), in patients on MHD at baseline and after a 1-year follow-up. Results: Fth1 was identified as a differentially expressed gene significantly upregulated in the aorta of both ApoE Conclusion: Elevated serum FTH and high serum phosphorus are clinically significant predictors of VC progression in patients on MHD.

Indexed as

ApoferritinsCoronary Artery DiseaseRenal DialysisVascular CalcificationAgedAnimalsBiomarkersDisease ProgressionFemaleFerritinsHumansMaleMiceMiddle AgedOxidoreductasesPredictive Value of TestsApoferritinsBiomarkersFerritinsFTH1 protein, humanOxidoreductasesferritin heavy chainmaintenance hemodialysispredictive valuerisk factorsvascular calcification

Identifiers

PMID40810067

DOI10.3389/fendo.2025.1503940

PMCPMC12343228

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.