ArticleFrontiers in endocrinology2025
Network pharmacological investigation and experimental verification of the peel of
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Natural products modulate renal metabolic reprogramming in diabetic kidney disease.Journal of translational internal medicine · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Methods: The components of YMP were systematically identified using UPLC-Q-TOF-MS/MS. A network pharmacology study between DN and significant components was then carried out. The pharmacological trials of YMP were evaluated in mice with diabetes. Results: 43 components were systematically identified from YMP. It was found by network pharmacology analysis that signal transduction, namely metabolic disruption, involved pathways with a high degree of engagement. Experimental verification showed that YMP administration increased glomerular hypertrophy, collagenous tissue proliferation, urine microalbumin/creatinine ratio, inflammatory response remission, and oxidative stress promotion Conclusions: This study was the first to show that YMP corrected disruptions in the pentose phosphate pathway and amino acid metabolism, alleviated diabetes-induced pathological changes in the kidneys of diabetic mice, and had a regulating effect on the liver glycolipid metabolism. By investigating the novel pharmacological effect of traditional Chinese medicine and encouraging in-depth study and development, this work may offer a new experimental foundation and theoretical direction for the sensible application of YMP on DN.
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