ArticleJHEP reports : innovation in hepatology2025
Implementation of a care bundle improves PBC management.
Article in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Treatment Goals for Primary Biliary Cholangitis, an Australian Perspective.Journal of gastroenterology and hepatology · 2026Review
- A Nationwide Assessment of Anticholestatic Therapy Uptake in Patients With Primary Biliary Cholangitis: Opportunities for Optimisation.Alimentary pharmacology & therapeutics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & Aims: In 2021, we conducted a UK-wide audit of the management of primary biliary cholangitis (PBC) in the National Health Service (NHS) of the UK, which identified widespread deficiencies in PBC-related healthcare. In the current study, recognising the need to address these deficiencies, we aimed to (1) develop a PBC care bundle to support clinicians in the provision of high-quality, standardised care; (2) pilot the bundle in selected centres across the UK; and (3) re-evaluate adherence to quality standards. Methods: We designed a PBC care bundle that incorporated a checklist of quality standards and a summary of guidelines from the British Society of Gastroenterology. Twelve hospitals, with variable performance in the national audit, were invited to pilot the bundle between 1 October 2023 and 31 March 2024. Clinical data were collected to compare adherence to quality standards before and after bundle use. Results: We obtained data about 773 patients with PBC. We found significant improvement in performance across all quality standards following bundle use, with two hospitals achieving target performance (≥90%) across all standards, something not achieved by any hospital in the national audit. Across all centres, referral of patients for second-line therapy increased from 72% to 94% ( Conclusions: Use of the PBC care bundle significantly improves adherence to management guidelines. Rollout of the bundle will mark a vital step to improve the delivery of high-quality care to all patients with PBC. Impact and implications: The national primary biliary cholangitis (PBC) audit demonstrated critical shortfalls in the delivery of PBC-related healthcare across the UK. In this study, we have designed a PBC care bundle to improve adherence to management guidelines and promote standardised care. We show that use of the bundle improves care delivery in hospitals across the NHS. The PBC care bundle has been endorsed by the British Society of Gastroenterology and the British Association for the Study of the Liver and is freely available online to all clinicians to support the provision of high-quality PBC-related healthcare.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.