ArticleJHEP reports : innovation in hepatology2025
Cholangiocarcinoma in Denmark: Time-trends in incidence and mortality.
Article in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Cholangiocarcinoma in Denmark: time trends in mortality following resection.International journal of surgery (London, England) · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
Background & Aims: Cholangiocarcinomas have a poor prognosis, and the incidence is rising in most countries. We examined time-trends in incidence and mortality in a nationwide Danish cohort. Methods: We used nationwide health databases to identify all Danish citizens diagnosed with cholangiocarcinoma from 1995 to 2022. We computed age-standardised incidence rates, stage distribution, and age- and sex-adjusted 1-year mortality. Results: The median age of the 5,787 patients with cholangiocarcinoma was 72 years, and 53% were female. Overall, the age-standardised incidence rate per 100,000 person-years almost doubled, from 3.93 (95% CI 3.59-4.26) in 1995-1998 to 6.79 (6.42-7.16) in 2019-2022. This rate increased five-fold for intrahepatic cholangiocarcinoma from 0.75 (0.61-0.90) in 1995-1998 to 3.85 (3.57-4.13) in 2019-2022, while for extrahepatic cholangiocarcinoma it decreased from 2.42 (2.16-2.69) in 1995-1998 to 1.30 (1.14-1.47) in 2019-2022. Although individuals aged 18-59 years had the lowest incidence rate of cholangiocarcinoma (any type), they experienced the steepest annual increase (3.2% Conclusion: The incidence of cholangiocarcinoma in Denmark increased in 1995-2022, driven by an increasing incidence of intrahepatic cholangiocarcinoma. Meanwhile, 1-year mortality decreased, likely reflecting earlier diagnosis and better treatments. Impact and implications: Cholangiocarcinomas have a poor prognosis, and the incidence is rising in most countries. In Europe, all countries but Denmark have shown an increasing incidence of intrahepatic cholangiocarcinoma. The incidence of cholangiocarcinoma in Denmark between 1995 and 2022 increased, driven by a large increase in intrahepatic cholangiocarcinomas. The proportion with localised resectable disease increased while 1-year mortality decreased, though it remained high (65% in 2019-2022). Knowledge of incidence and mortality risk is valuable for doctors to understand the disease, identify risk factors, and design preventive care studies; for healthcare providers to allocate resources; and for patients to understand their prognosis.
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