ArticleACS pharmacology & translational science2025
Transport of Small Aliphatic Amines by Polyspecific Solute Carriers: Deciphering Structure-Function Relationships.
Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Membrane proteins of the solute carrier (SLC) 22A and 47A families are polyspecific transporters critical for handling diverse endogenous and exogenous compounds, including many clinically relevant drugs. However, their substrate specificity remains poorly understood. To address this, we conducted a structure-function relationship analysis focusing on small aliphatic amines (alkylamines and alkanolamines) and enantioselectivity of their transport. Using HEK293 cells stably overexpressing organic cation transporters (OCT) 1, 2, or 3 (
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