Evidence map›Paper›PMID 40810218›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Qufeng Jiejing formula ameliorated the injury of airway smooth muscle cells induced by platelet-derived growth factor-BB through the transforming growth factor-β1/Smads signaling pathway.

Fan Changzheng, Zhang Qiong, Fan Maorong, Meng Hongxu, Cong Xiaodong, Fan Yiling, Yuan Shasha, Miao Qing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Fan ChangzhengRespiratory Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Zhang QiongRespiratory Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Fan MaorongRespiratory Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Meng HongxuInstitute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Cong XiaodongRespiratory Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Fan YilingRespiratory Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Yuan ShashaRespiratory Department, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Miao QingRespiratory Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.

Funding

Cultivation Project of The National Natural Science Foundation of China of Xiyuan Hospital, China Academy of Chinese Medical Sciences of Research on the Role of Traditional Chinese Medicines-Qufeng Jiejing in the Proliferation, Migration and Phenotypic Transformation of Airway Smooth Muscle Cells in Asthma XY20-17Science and Technology Innovation Project of China Academy of Chinese Medical Sciences of Study on the Mechanism of Qufeng Jiejing Formula in Regulating Mitogen-activated Protein Kinase Signaling Pathway to Inhibit Phenotypic Transformation of Airway Smooth Muscle Cells in Asthma CI2021A01108
6 · The paper itself

Abstract

objectiveTo explore the role and mechanism of Qufeng Jiejing (，QFJJ) formula in the asthma progression.

methodsThe Bagg Albino/c mice treated with Ovalbumin and AL(OH)3, and airway smooth muscle cells (ASMCs) treated with platelet-derived growth factor (PDGF)-BB to establish a asthma model in vivo and in vitro. The cell morphology was observed with microscope and immunofluorescence staining. The cell viability was assessed with methyl thiazolyl tetrazolium assay. The tumor necrosis factor-αlpha (TNF-α), interleukin-1beta (IL-1β), laminin, fibronectin and collagen IV levels in the ASMCs were detected with corresponding enzyme linked immunosorbent assay kits. Transwell and wound healing assays were conducted to test the cell migration. The TGF-β1, Smad2 and Smad3 levels were measured with Western blot.

resultsWe found that QFJJ formula treatment dramatically decreased the cell viability, TNF-α, IL-1β, laminin, fibronectin and collagen IV levels in the PDGF-BB stimulated ASMCs. Additionally, the protein levels of TGF-β1, Smad2 and Smad3 in the PDGF-BB stimulated ASMCs were prominently depleted after QFJJ formula treatment. Besides, SRI treatment neutralized the role of QFJJ formula in the PDGF-BB stimulated ASMCs.

conclusionQFJJ formula effectively relieved the asthma progression through ameliorate the ASMCs function, which was achieved through suppressing the TGF-β1/Smads signaling pathway.

Indexed as

AsthmaDrugs, Chinese HerbalMyocytes, Smooth MuscleProto-Oncogene Proteins c-sisSignal TransductionSmad ProteinsTransforming Growth Factor beta1AnimalsBecaplerminFemaleHumansMaleMiceMice, Inbred BALB CBecaplerminDrugs, Chinese HerbalProto-Oncogene Proteins c-sisSmad ProteinsTransforming Growth Factor beta1asthmamyocytes, smooth muscleQufeng Jiejing formulasignal transductionSmad proteinstransforming growth factor beta1

Identifiers

PMID40810218
PMCPMC12340578

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.