Evidence map›Paper›PMID 40810220›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Huayu Qutan formula can improve platelet aggregation in acute coronary syndrome rats by regulating gut microbes to drive trimethylamine/flavin containing monooxygenase 3/trimethylamine N-oxide pathway.

Zhang Ni, Chen Yanxi, Jia Lianqun, L I Xinya, M A Yixin

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Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Zhang NiDepartment of Cardiology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China.
Chen YanxiFirst Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China.
Jia LianqunDepartment of Biochemistry, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China.
L I XinyaFirst Clinical College, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China.
M A YixinChinese Medicine Innovation Engineering Technology Center, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China.

Funding

Education Department of Liaoning Province Young Science and Technology Talents "Seedling" Project: to Explore the Effect and Mechanism of Huayu Qutan Formula on Platelet Function in Acute Coronary Syndrome Patients with Phlegm and Blood Stasis Syndrome after Percutaneous Coronary Intervention based on Intestinal Microbiome L202039National Natural Science Foundation of China Project: based on the Theory of "the Heart is in Harmony with the Small Intestine" to Explore the Influence and Mechanism of Gut Microbes on High Platelet Reactivity of Acute Coronary Syndrome with Phlegm and Blood Stasis Syndrome 82104841
6 · The paper itself

Abstract

objectiveTo investigate the effects of gut microbes regulation of the trimethylamine (TMA)/flavin containing monooxygenase 3 (FMO3)/trimethylamine N-oxide (TMAO) pathway on platelet aggregation in acute coronary syndrome (ACS) rats and the intervention of Huayu Qutan formula.

methodsThe ACS rats with syndrome of phlegm and blood stasis rats were established. Platelet, platelet aggregation, platelet activation markers and TMA/FMO3/ TMAO pathway were detected. Metagenomics technology was employed to analyze the characteristics of the gut microbiota.

resultsHuayu Qutan formula and gut microbes could inhibit high platelet reactivity and regulate the TMA/ FMO3/TMAO pathway. The dominant bacteria in ACS rats including but not limited to the major phyla, Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria, also including some low abundance phyla, Fusobacteria, Verrucomicrobia, Spirochaetes, and Deferribacteres. The dominant bacteria in the Huayu Qutan formula group were Synergistetes, Deferribacteres, Deferribacteraceae,

conclusionHuayu Qutan formula may prevent ACS by modulating gut microbes Synergistetes,

Indexed as

Acute Coronary SyndromeDrugs, Chinese HerbalGastrointestinal MicrobiomeMethylaminesOxygenasesPlatelet AggregationAnimalsBacteriaHumansMaleRatsRats, Sprague-Dawleydimethylaniline monooxygenase (N-oxide forming)Drugs, Chinese HerbalMethylaminesOxygenasestrimethylaminetrimethyloxamineacute coronary syndromegut microbesHuayu Qutan formulaplatelet aggregation

Identifiers

PMID40810220
PMCPMC12340591

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.